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First experience with a novel luminescence-based optical sensor for measurement of oxygenation in tumors
Jarm, Tomaž (Avtor), Lešničar, Hotimir (Avtor), Serša, Gregor (Avtor), Miklavčič, Damijan (Avtor)

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Izvleček
Background. The purpose of this preliminary study was to evaluate a novel luminescence-based fiber-optic sensor (OxyLite system) for the measurement of partial pressure of oxygen (pO2) in tumors and for the detection of changes inpO2 as a function of time. The new method was used simultaneously with the laser Doppler flowmetry method for the measurement of relative tissue perfusion. Materials and methods. Blood perfusion and pO2 were measured continuously via fiber-optic sensors inserted into SA-1 tumors in anesthetizedAžJ mice. The changes in blood flow and oxygenation of tumors wereinduced by transient changes of the parameters of anesthesia and by injection of a vasoactive drug hydralazine. Results. Both optical methods usedin the study successfully detected the induced changes in blood flow and pO2. The measurements of pO2 were well correlated with measurements of microcirculatory blood perfusion. In the majority of pO2 measurements, we observed an unexpected behavior of the signal during the stabilization processimmediately after the insertion of the probe into tumor. This behaviourof the pO2 signal was most probably caused by local tissue damage induced by the insertion of the probe. Conclusion. The novel luminescence-based optical oximetry can reliably detect local pO2 changes in tumors as a function of time but some aspects of prolonged pO2 measurement by this method require further investigation.

Jezik:Angleški jezik
Ključne besede:eksperimentalni sarkom, pretok krvi, metoda laser Doppler, oksigenacija, luminescenca, sarcoma experimental, blood supply, laser-doppler flowmetry, oxygen, luminiscence
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FE - Fakulteta za elektrotehniko
Leto izida:2001
Založnik:Croatian Medical Association - Croatian Society of Radiology
Št. strani:str. 277-291
Številčenje:Vol. 35, no. 4
UDK:616-006
ISSN pri članku:1318-2099
COBISS.SI-ID:2531156 Povezava se odpre v novem oknu
Število ogledov:361
Število prenosov:150
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Neznan jezik
Naslov:Prve izkušnje z novo luminiscenčno optično metodo za merjenje oksigenacije v tumorjih

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