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Možnosti uporabe genskega dopinga in problemi njegove detekcije
Žiberna, Lovro (Author), Žiberna, Klemen (Author), Štrukelj, Borut (Author), Mlinarič-Raščan, Irena (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-IQD3FYIY This link opens in a new window

Abstract
Genski doping je neterapevtska uporaba celic, genov, genskih elementov ali modulacija genske ekspresije, katere cilj je izboljsati sposobnosti sportnika.Namen vnosa genskega materiala v celice tarènih tkiv je poveèana ekspresija proteinov, ki regulirajo signalne poti in povzroèijo izboljsanje zelenih fizioloskih parametrov. Vnosi genskih zapisov za eritropoetin, IGF-1, inhibitorje miostatina, VEGF in PPAR-delta v celice tarènih tkiv zivali izboljsajo aerobne sposobnosti, podaljsajo vzdrzljivost in zveèajo misièno moè. Tezave z uèinkovitostjo in specifiènostjo prenosa genskega materiala v telo predstavljajo tveganje za organizem. Zaenkrat se ne poznamo primernega testa za detekcijo genskega dopinga, ki bi imel ustrezno obèutljivost in specifiènost ter bi bil hkrati neinvaziven.

Language:Slovenian
Keywords:genski doping, eritropoetin, IGF-1, miostatin, detekcija dopinga, PPAR-delta, VEGF
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2007
Publisher:Slovensko farmacevtsko društvo
Number of pages:str. 139-144
Numbering:Letn. 58, št. 4
UDC:61
ISSN on article:0014-8229
COBISS.SI-ID:2230897 Link is opened in a new window
Views:682
Downloads:134
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Record is a part of a journal

Title:Farmacevtski vestnik
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 This link opens in a new window

Secondary language

Language:English
Title:An overview of gene doping applications and problems of its detection
Abstract:
Gene doping is defined as the non-therapeutic use of cells, genes, genetic elements, or of the modulation of gene expression, having the capacity to enhance athletic performance. The purpose of gene insertion into the target cells is to improve physiological abilities by vast production of protein thatamplifies or inhibits certain signalling pathways. Insertion of genes for erythropoietin, IGF-1, myostatin inhibitors, VEGF and PPAR-delta in animals has shown major rise in aerobic capabilities, prolonged endurance and increased muscle strength. However, several problems with efficiency and specificity of gene transfer exist and call attention to safety and health concerns. Also, no adequate non-invasive and sensitive detection method exists for gene doping.


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