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Numerical modeling in electroporation-based biomedical applications
Pavšelj, Nataša (Avtor), Miklavčič, Damijan (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.dlib.si/details/URN:NBN:SI:doc-PZ8WD43D Novo okno

Izvleček
Background. Numerous experiments have to be performed before a biomedical application is put to practical use in clinical environment. As a complementary work to in vitro, in vivo and medical experiments, we can use analytical and numerical models to represent, as realistically as possible, real biological phenomena of, in our case, electroporation. In this way we canevaluate different electrical parameters in advance, such as pulse amplitude, duration, number of pulses, or different electrode geometries. Suchnumerical models can contribute significantly to the understanding of an experiment and treatment planning as well as to the design of new electroporation devices and electrodes. Methods. We used commercially available modeling software, based on finite element method. We constructed a model of a subcutaneous tumor during electrochemotherapy (EMAS) and a model ofskin during gene electrotransfer (COMSOL Multiphysics). Tissue-electrode geometries, pulse parameters and currentvoltage measurements from in vivo experiments were used to develop and validate the models. Results. To describeadequately our in vivo observations, a tissue conductivity increase during electroporation was included in our numerical models. The output currents of the models were compared to the currents and the voltages measuredduring in vivo experiments and a good agreement was obtained. Also, when comparing the voltages needed for a successful electropermeabilization assuggested by the models, to voltages applied in experiments and achieving a successful electrochemotherapy or in vivo gene electrotransfer, good agreementcan be observed. Conclusions. Modeling of electric current and electric field distribution during cell and tissue electroporation proves to be helpful in describing different aspects of the process and allowing us to design electrodes and electroporation protocols as a part of treatment planning.

Jezik:Angleški jezik
Ključne besede:elektroporacija, genska elektrotransfekcija, elektrokemoterapija, podkožni tumor, metoda končnih elementov, electroporation, gene electrotransfer, electrochemotherapy, subcutaneous tumor, finite-element method
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FE - Fakulteta za elektrotehniko
Leto izida:2008
Založnik:Croatian Medical Association - Croatian Society of Radiology
Št. strani:str. 159-168
Številčenje:Vol. 42, no. 3
UDK:616-006
ISSN pri članku:1318-2099
COBISS.SI-ID:6697300 Povezava se odpre v novem oknu
Število ogledov:425
Število prenosov:118
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Naslov:[Numerično modeliranje elektroporacije v tkivih]

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