The developement of new pharmaceutical excipients is proceeding simultaneouslywith developement of new active pharmaceutical ingredients. The purpose of the developement of new pharmaceutical excipients is to achieve desirable properties in dosage forms like controlled release, improved bioavailabilty, enhanced stability etc. An example of new excipients are interpolymer complexes (IPC), which can obtain completely different propertiescompared to separate original polymers. The developement and properties of IPC are essentially influenced by manufacturing parameters. In this article we also present some experimental cases of the usage of IPC in pharmaceutical technology beside important manufacturing parameters. The feasibilities of the usage of computer models for developement of optimal conditions for IPC assembly are also pointed out. We can conclude that the research of influence and applications of IPC on formulation of dosage forms are nowadays the topic of great interest in pharmaceutical techology.