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Interpolimerni kompleksi
Pavli, Matej (Author), Vrečer, Franc (Author), Baumgartner, Saša (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-YHPBCI2Y This link opens in a new window

Abstract
Razvoj novih pomožnih snovi poteka sočasno z razvojem novih učinkovin. Namen razvoja novih pomožnih snovi je doseganje želenih lastnosti farmacevtskih oblik, kot so: nadzorovano sproščanje, izboljšanje biološke uporabnosti, poveoeana stabilnost idr. Primer novih pomožnih snovi so interpolimerni kompleksi (IPC), ki lahko izkazujejo povsem drugačne lastnosti od posameznih izhodiščnih polimerov. Na nastanek in lastnosti IPC imajo ključen vpliv parametri izdelave. V članku poleg ključnih parametrov izdelave obravnavamo tudi nekaj konkretnih primerov uporabe IPC v farmacevtski tehnologiji. Nakazane so tudi možnosti uporabe računalniških modelov za načrtovanje optimalnih pogojev za nastanek IPC. Zaključimo lahko,da so raziskave vpliva in uporabnosti IPC pri oblikovanju farmacevtskih oblik danes v farmacevtski tehnologiji zelo aktualne.

Language:Slovenian
Keywords:nadzorovano sproščanje, pomožne snovi, polimeri, kompleksi, farmacevtske oblike
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Year:2008
Publisher:Slovensko farmacevtsko društvo
Number of pages:str. 121-127
Numbering:Let. 59, št. 3
UDC:66.02+661.12
ISSN on article:0014-8229
COBISS.SI-ID:2364273 Link is opened in a new window
Views:508
Downloads:101
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Record is a part of a journal

Title:Farmacevtski vestnik
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 This link opens in a new window

Secondary language

Language:English
Title:Intepolymer complexes
Abstract:
The developement of new pharmaceutical excipients is proceeding simultaneouslywith developement of new active pharmaceutical ingredients. The purpose of the developement of new pharmaceutical excipients is to achieve desirable properties in dosage forms like controlled release, improved bioavailabilty, enhanced stability etc. An example of new excipients are interpolymer complexes (IPC), which can obtain completely different propertiescompared to separate original polymers. The developement and properties of IPC are essentially influenced by manufacturing parameters. In this article we also present some experimental cases of the usage of IPC in pharmaceutical technology beside important manufacturing parameters. The feasibilities of the usage of computer models for developement of optimal conditions for IPC assembly are also pointed out. We can conclude that the research of influence and applications of IPC on formulation of dosage forms are nowadays the topic of great interest in pharmaceutical techology.


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