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Image cytometric nuclear texture features in inoperable head and neck cancer : a pilot study
Strojan Fležar, Margareta (Avtor), Lavrenčak, Jaka (Avtor), Žganec, Mario (Avtor), Strojan, Primož (Avtor)

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Izvleček
Background. Image cytometry can measure numerous nuclear features which could be considered a surrogate end-point marker of molecular genetic changes in a nucleus. The aim of the study was to analyze image cytometric nuclear featuresin paired samples of primary tumor and neck metastasis in patients with inoperable carcinoma of the head and neck. Materials and methods. Image cytometric analysis of cell suspensions prepared from primary tumor tissue andfine needle aspiration biopsy cell samples of neck metastases from 21 patients treated with concomitant radiochemotherapy was performed. Nuclear features were correlated with clinical characteristics and response to therapy. Results. Manifestation of distant metastases and new primaries was associated (p<0.05) with several chromatin characteristics from primary tumor cells, whereas the origin of index cancer and disease response in the neck wasrelated to those in the cells from metastases. Many nuclear features of primary tumors and metastases correlated with the TNM stage. Conclusions. A specific pattern of correlation between well-established prognostic indicatorsand nuclear features of samples from primary tumors and those from neck metastases was observed. Image cytometric nuclear features represent a promising candidate marker for recognition of biologically different tumor subgroups.

Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2011
Založnik:Croatian Medical Association - Croatian Society of Radiology
Št. strani:str. 40-45
Številčenje:Vol. 45, no. 1
UDK:616-006.6:611.91/.93
ISSN pri članku:1318-2099
DOI:10.2478/v10019-011-0002-y Povezava se odpre v novem oknu
COBISS.SI-ID:28182745 Povezava se odpre v novem oknu
Število ogledov:1131
Število prenosov:144
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Naslov:Radiology and oncology
Skrajšan naslov:Radiol Oncol
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Povezava se odpre v novem oknu

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Jezik:Slovenski jezik
Naslov:a pilot study

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