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In vitro modeli za preučevanje metabolizma učinkovin v jetrih
Trdan Lušin, Tina (Author), Trontelj, Jurij (Author)

URLURL - Presentation file, Visit http://www.sfd.si/modules/catalog/products/prodfile/fv_4_2011_nr.pdf This link opens in a new window

Abstract
V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfundirana jetra. Predstavljene so njihove prednosti, slabosti in omejitve ter področja uporabe.

Language:Slovenian
Keywords:metabolizem, zdravilne učinkovine, eksperimentalni modeli, in vitro modeli, subcelične frakcije
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Year:2011
Publisher:Slovensko farmacevtsko društvo
Number of pages:str. 171-174
Numbering:Letn. 62, št. 4
UDC:576.34:615
ISSN on article:0014-8229
COBISS.SI-ID:3133041 Link is opened in a new window
Views:847
Downloads:208
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Record is a part of a journal

Title:Farmacevtski vestnik
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 This link opens in a new window

Secondary language

Language:English
Title:In vitro models for investigation of drug metabolism in the liver
Abstract:
This article gives a systematic review of in vitro experimental models for hepatic drug metabolism. The presented models include: recombinant enzymes, microsomes, cytosol, S9 fraction, isolated hepatocytes, cell lines, liver tissue slices and perfused liver. For each model, a comprehensive overview is given, including application, benefits, and drawbacks.


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