In vitro modeli za preučevanje metabolizma učinkovin v jetrih

Trdan Lušin, Tina (author), Trontelj, Jurij (author)

V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfundirana jetra. Predstavljene so njihove prednosti, slabosti in omejitve ter področja uporabe.

• Language: Slovenian
• Keywords: metabolizem, zdravilne učinkovine, eksperimentalni modeli, in vitro modeli, subcelične frakcije
• Work type: Not categorized (r6)
• Tipology: 1.02 - Review Article
• Organization: FFA - Faculty of Pharmacy
• Year: 2011
• Publisher: Slovensko farmacevtsko društvo
• Number of pages: str. 171-174
• Numbering: Letn. 62, št. 4
• UDC: 576.34:615
• ISSN on article: 0014-8229
• COBISS.SI-ID: 3133041
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Record is a part of a journal

• Title: Farmacevtski vestnik
• Shortened title: Farm. vestn.
• Publisher: Slovensko farmacevtsko društvo
• ISSN: 0014-8229
• COBISS.SI-ID: 3105794

Secondary language

• Language: English
• Title: In vitro models for investigation of drug metabolism in the liver

Abstract

This article gives a systematic review of in vitro experimental models for hepatic drug metabolism. The presented models include: recombinant enzymes, microsomes, cytosol, S9 fraction, isolated hepatocytes, cell lines, liver tissue slices and perfused liver. For each model, a comprehensive overview is given, including application, benefits, and drawbacks.