izpis_h1_title_alt

Zaščitni pleiotropni učinki statinov
Lunder, Mojca (Avtor), Žiberna, Lovro (Avtor), Drevenšek, Gorazd (Avtor), Šabovič, Mišo (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://szd.si/user_files/vsebina/Zdravniski_Vestnik/2011/januar/39-49.pdf Novo okno

Izvleček
Background: Statins are recognised as the most effective lipid-lowering drugs.The main mechanism of action is the inhibition of 3-hydroxy-methylglutaryl-coenzyme A reductase, which is a key enzyme in the cholesterol synthesis pathway. Statins also have additional effects, known as pleiotropic effects, which are mostly due to the inhibition of the formation of non-steroidal isoprenoids. The latter have important functions in the activation of many intracellular signalling pathways. Consequently, statins improve endothelial function, have anti-inflammatory and immunomodulatory activity, act as antioxidants, stabilize atherosclerotic plaques and influencehaemostasis and thrombosis. The described mechanisms are particularlyrelevant in the protective activity of statins on the cardiovascular system, central nervous system, kidneys and many other organs. Conclusions: In the current article we review the pharmacological mechanisms of action, which contribute to the beneficial pleiotropic effects of statins. Described mechanisms are supported by the evidence obtained from clinical trials in the last decade.

Jezik:Slovenski jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2011
Založnik:Slovensko zdravniško društvo
Št. strani:str. 39-49
Številčenje:Letn. 80, št. 1
UDK:615.2
ISSN pri članku:1318-0347
COBISS.SI-ID:27863769 Povezava se odpre v novem oknu
Število ogledov:583
Število prenosov:101
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:Zdravniški vestnik
Založnik:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Naslov:Beneficial pleiotropic effects of statins

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