Illustrated and illuminated European medieval manuscripts are fundamental materials which enable continuous observation of cultural development, from the antique to the present days. Rare and precious work are attainable to the public and scholars mainly through facsimile editions that pass over as hand made subjectivity influenced copies, as well as the state of the art achievements of publishing and printing industry. Techniques of accurate presentation of object shapes were well known to the artists and printers since the early Renaissance period, but important improvements became available in the 19th century as photographic and photomechanic reproduction techniques. Modern digitalised reproduction techniques are giving us best results in the facsimile production. Faultless facsimile of paleographic, art history, visual art, national, political and cultural documents as well asthe works of the other important fields of interest, equiped with corresponding comments, now remain important cultural artefact of the given period. They are monuments to the original itself as well as a proof of technical culture of those manufacturers, who recreated the original using facsimile techniques. Moreover some reproductions remained sole remnants of the lost or stolen, burnt or otherwise ruined originals. In this thesis the development of the reproduction methods, of the manuscrips and of the facsimile techniques are presented. There is also a presentation of the evaluation trial of the facsimile similarity compared to the original, as well as evaluation of the impact of the facsimile on a cultural and scientific development as a whole.