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Resting state functional connectivity of five neural networks in bipolar disorder and schizophrenia
Mamah, Daniel (Avtor), Repovš, Grega (Avtor), Barch, Deanna M. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0165032713001766 Povezava se odpre v novem oknu

Izvleček
Background: Bipolar disorder (BPD) and schizophrenia (SCZ) share clinical characteristics and genetic contributions. Functional dysconnectivity across various brain networks has been reported to contribute to the pathophysiology of both SCZ and BPD. However, research examining resting-state neural network dysfunction across multiple networks to understand the relationship between these two disorders is lacking. Methods: We conducted a resting-state functional connectivity fMRI study of 35 BPD and 25 SCZ patients, and 33 controls. Using previously defined regions-of-interest, we computed the mean connectivity within and between five neural networks: default mode (DM), fronto-parietal (FP), cingulo-opercular (CO), cerebellar (CER), and salience (SAL). Repeated measures ANOVAs were used to compare groups, adjusting false discovery rate to control for multiple comparisons. The relationship of connectivity with the SANS/SAPS, vocabulary and matrix reasoning was investigated using hierarchical linear regression analyses. Results: Decreased within-network connectivity was only found for the CO network in BPD. Across groups, connectivity was decreased between CO-CER (p<0.001), to a larger degree in SCZ than in BPD. In SCZ, there was also decreased connectivity in CO-SAL, FP-CO, and FP-CER, while BPD showed decreased CER-SAL connectivity. Disorganization symptoms were predicted by connectivity between CO-CER and CER-SAL. Discussion: Our findings indicate dysfunction in the connections between networks involved in cognitive and emotional processing in the pathophysiology of BPD and SCZ. Both similarities and differences in connectivity were observed across disorders. Further studies are required to investigate relationships of neural networks to more diverse clinical and cognitive domains underlying psychiatric disorders.

Jezik:Angleški jezik
Ključne besede:shizofrenija, bipolarna motnja, funkcijska konektivnost, možgani, nevronske mreže, schizophrenia, bipolar disorder, functional connectivity, brain, neural newtorks
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FF - Filozofska fakulteta
Leto izida:2013
Št. strani:str. 601-609
Številčenje:Vol. 150, iss. 2
UDK:159.91:616.895
ISSN pri članku:0165-0327
DOI:10.1016/j.jad.2013.01.051 Povezava se odpre v novem oknu
COBISS.SI-ID:52473186 Povezava se odpre v novem oknu
Število ogledov:748
Število prenosov:246
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Journal of affective disorders
Skrajšan naslov:J. affective disord.
Založnik:Elsevier/North-Holland
ISSN:0165-0327
COBISS.SI-ID:6323719 Povezava se odpre v novem oknu

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