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NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic, Alan (Avtor), Repovš, Grega (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.pnas.org/content/109/41/16720.full Povezava se odpre v novem oknu

Izvleček
Glutamatergic neurotransmission mediated by N-methyl-d-aspartate (NMDA) receptors is vital for the cortical computations underlying cognition and might be disrupted in severe neuropsychiatric illnesses such as schizophrenia. Studies on this topic have been limited to processes in local circuits; however, cognition involves large-scale brain systems with multiple interacting regions. A prominent feature of the human brainʼs global architecture is the anticorrelation of default-mode vs. task-positive systems. Here, we show that administration of an NMDA glutamate receptor antagonist, ketamine, disrupted the reciprocal relationship between these systems in terms of task-dependent activation and connectivity during performance of delayed working memory. Furthermore, the degree of this disruption predicted task performance and transiently evoked symptoms characteristic of schizophrenia. We offer a parsimonious hypothesis for this disruption via biophysically realistic computational modeling, namely cortical disinhibition. Together, the present findings establish links between glutamateʼs role in the organization of large-scale anticorrelated neural systems, cognition, and symptoms associated with schizophrenia in humans.

Jezik:Angleški jezik
Ključne besede:shizofrenija, funkcijsko magnetnoresonančno slikanje (fMRI), mirovno omrežje, psihofarmakologija, kognitivna nevroznanost, schizophrenia, functional magnetic resonance imaging (fMRI), default network, psychopharmacology, cognitive neuroscience
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FF - Filozofska fakulteta
Leto izida:2012
Št. strani:str. 16720-16725
Številčenje:Vol. 109, no. 41
UDK:159.95:611.81
ISSN pri članku:0027-8424
DOI:10.1073/pnas.1208494109 Povezava se odpre v novem oknu
COBISS.SI-ID:50133602 Povezava se odpre v novem oknu
Število ogledov:838
Število prenosov:497
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Gradivo je del revije

Naslov:Proceedings of the National Academy of Sciences of the United States of America
Skrajšan naslov:Proc. Natl. Acad. Sci. U. S. A.
Založnik:National Academy of Sciences
ISSN:0027-8424
COBISS.SI-ID:286487 Povezava se odpre v novem oknu

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