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Working memory encoding and maintainance deficits in schizophrenia : neural evidence for activaction and deactivation abnormalities
Anticevic, Alan (Avtor), Repovš, Grega (Avtor), Barch, Deanna M. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://schizophreniabulletin.oxfordjournals.org/content/early/2011/09/12/schbul.sbr107.full.pdf+html Povezava se odpre v novem oknu

Izvleček
Substantial evidence implicates working memory (WM) as a core deficit in schizophrenia (SCZ), purportedly due to primary deficits in dorsolateral prefrontal cortex functioning. Recent findings suggest that SCZ is also associated with abnormalities in suppression of certain regions during cognitive engagementŽnamely the default mode systemŽ that may further contribute to WM pathology. However, no study has systematically examined activation and suppression abnormalities across both encoding and maintenance phases of WM in SCZ. Twenty-eight patients and 24 demographically matched healthy subjects underwent functional magnetic resonance imaging at 3T while performing a delayed match-to-sample WM task. Groups were accuracy matched to rule out performance effects. Encoding load was identical across subjects to facilitate comparisons across WM phases. We examined activation differences using an assumed model approach at the wholebrain level and within meta-analytically definedWMareas. Despite matched performance, we found regions showing less recruitment during encoding and maintenance for SCZ subjects. Furthermore, we identified 2 areas closely matching the default system, which SCZ subjects failed to deactivate across WM phases. Lastly, activation in prefrontal regions predicted the degree of deactivation for healthy but not SCZ subjects. Current results replicate and extend prefrontal recruitment abnormalities across WMphases in SCZ. Results also indicate deactivation abnormalities across WM phases, possibly due to inefficient prefrontal recruitment. Such regional deactivation may be critical for suppressing sources of interference duringWM trace formation. Thus, deactivation deficits may constitute an additional source of impairments, which needs to be further characterized for a complete understanding of WM pathology in SCZ.

Jezik:Angleški jezik
Ključne besede:shizofrenija, funkcijsko magnetnoresonančno slikanje (fMRI), delovni spomin, vkodiranje, vzdrževanje, mirovno omrežje, schizophrenia, functional magnetic resonance imaging (fMRI), working memory, encoding, maintenance, default network
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FF - Filozofska fakulteta
Leto izida:2013
Št. strani:str. 168-178
Številčenje:Vol. 39, no. 1
UDK:159.953:616.895.8
ISSN pri članku:0586-7614
DOI:10.1093/schbul/sbr107 Povezava se odpre v novem oknu
COBISS.SI-ID:47038306 Povezava se odpre v novem oknu
Število ogledov:459
Število prenosov:148
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Schizophrenia bulletin
Skrajšan naslov:Schizophr. bull.
Založnik:U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, [Supt. of Docs., U.S. G.P.O., distributor]
ISSN:0586-7614
COBISS.SI-ID:514686745 Povezava se odpre v novem oknu

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