izpis_h1_title_alt

Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia
Anticevic, Alan (Avtor), Repovš, Grega (Avtor), Barch, Deanna M. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://schizophreniabulletin.oxfordjournals.org/content/38/5/967.full.pdf+html?sid=47e3a030-df38-49ed-9c74-93801d368a1f Povezava se odpre v novem oknu

Izvleček
Emotional abnormalities are a critical clinical feature of schizophrenia (SCZ), but complete understanding of their underlying neuropathology is lacking. Numerous studies have examined amygdala activation in response to affective stimuli in SCZ, but no consensus has emerged. However, behavioral studies examining "in-the-moment" processing of affect have suggested intact emotional processing in SCZ. To examine which aspects of emotional processing may be impaired in SCZ, we combined behavior and neuroimaging to investigate effects of aversive stimuli during minimal cognitive engagement, at the level of behavior, amygdala recruitment, and its whole-brain task-based functional connectivity (tb-fcMRI) because impairments may manifest when examining across-region functional integration. Twenty-eight patients and 24 matched controls underwent rapid event-related fMRI at 3 T while performing a simple perceptual decision task with negative or neutral distraction. We examined perceptual decision slowing, amygdala activation, and whole-brain amygdala tb-fcMRI, while ensuring group signal-to-noise profile matching. Following scanning, subjects rated all images for experienced arousal and valence. No significant group differences emerged for negative vs neutral reaction time, emotional ratings across groups, or amygdala activation. However, even in the absence of behavioral or activation differences, SCZ subjects demonstrated significantly weaker amygdala- prefrontal cortical coupling, specifically during negative distraction. Whereas in-the-moment perception, behavioral response, and amygdala recruitment to negative stimuli during minimal cognitive load seem to be intact, there is evidence of aberrant amygdala-prefrontal integration in SCZ subjects. Such abnormalities may prove critical for understanding disturbances in patients' ability to use affective cues when guiding higher level cognitive processes needed in social interactions.

Jezik:Angleški jezik
Ključne besede:shizofrenija, funkcijsko magnetnoresonančno slikanje (fMRI), amigdala, pozornost, čustva, funkcionalna konektivnost, Mednarodni sistem emocionalnih fotografij (IAPS), schizophrenia, functional magnetic resonance imaging (fMRI), amygdala, attention, emotions, functional connectivity, International affective picture system (IAPS)
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FF - Filozofska fakulteta
Leto izida:2012
Št. strani:str. 967-980
Številčenje:Vol. 38, no. 5
UDK:159.942:616.895.8
ISSN pri članku:0586-7614
DOI:10.1093/schbul/sbq168 Povezava se odpre v novem oknu
COBISS.SI-ID:46635874 Povezava se odpre v novem oknu
Število ogledov:738
Število prenosov:258
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Schizophrenia bulletin
Skrajšan naslov:Schizophr. bull.
Založnik:U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, [Supt. of Docs., U.S. G.P.O., distributor]
ISSN:0586-7614
COBISS.SI-ID:514686745 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj