Genetic diversity of HPV-6 in concurrent multiple anogenital warts

Fujs Komloš, Kristina (avtor), Košorok, Pavle (avtor), Kocjan, Boštjan (avtor), Poljak, Mario (avtor)

Introduction: Anogenital warts (AGW) are the most common benign tumors in the anogenital area. They are etiologically associated with alpha human papillomaviruses (HPV), in more than 90% of cases with HPV-6 and HPV-11. AGW frequently displays a multifocal and multicentric appearance. However, it is not clear whether the occurrence of multiple AGW in a particular patient is a consequence of infection with single or multiple HPV genomic variants of a given HPV genotype. Methods: Forty-five HPV-6 isolates from fresh-frozen AGW tissue specimens, obtained from 18 patients with concurrent multiple AGW, were included. The entire HPV-6 L1, E5a, E5b ORFs, and LCR genomic region was sequenced. Results: Fourteen different HPV-6 L1-LCR-E5a-E5b genomic variants were identified among 18 patients with concurrent multiple AGW. In 17 out of 18 patients, a single identical HPV-6 L1-E5a-E5b-LCR genomic variant was identified in all concurrent multiple AGW collected in an individual patient. Co-infection with two different HPV-6 genomic variants was identified in one patient. Discussion: The presence of an identical HPV genomic variant in all concurrently present multiple AGW within an individual patient supports the hypothesis that the occurrence of multiple concurrent AGW is a consequence of infection with a single HPV-6 genomic variant, rather than infection with multiple genomic variants of HPV-6.

• Jezik: Angleški jezik
• Ključne besede: HPV-6 virus, anogenitalne bradavice, genetika
• Vrsta gradiva: Delo ni kategorizirano (r6)
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Leto izida: 2013
• Št. strani: str. 31-33
• Številčenje: Vol. 22, no. 1
• UDK: 578
• ISSN pri članku: 1318-4458
• DOI: 10.2478/v10162-012-0028-x
• COBISS.SI-ID: 30628313
• Skupna ocena: (0 glasov)
• Vaša ocena: Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

• Naslov: Acta dermatovenerologica Alpina, Panonnica et Adriatica
• Skrajšan naslov: Acta dermatovenerolog. Alp. Panon. Adriat.
• Založnik: Slovene Welding Society
• ISSN: 1318-4458
• COBISS.SI-ID: 31649024