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Genetic diversity of HPV-6 in concurrent multiple anogenital warts
Fujs Komloš, Kristina
(
Avtor
),
Košorok, Pavle
(
Avtor
),
Kocjan, Boštjan
(
Avtor
),
Poljak, Mario
(
Avtor
)
URL - Predstavitvena datoteka, za dostop obiščite
http://www.acta-apa.org/
Izvleček
Introduction: Anogenital warts (AGW) are the most common benign tumors in the anogenital area. They are etiologically associated with alpha human papillomaviruses (HPV), in more than 90% of cases with HPV-6 and HPV-11. AGW frequently displays a multifocal and multicentric appearance. However, it is not clear whether the occurrence of multiple AGW in a particular patient is a consequence of infection with single or multiple HPV genomic variants of a given HPV genotype. Methods: Forty-five HPV-6 isolates from fresh-frozen AGW tissue specimens, obtained from 18 patients with concurrent multiple AGW, were included. The entire HPV-6 L1, E5a, E5b ORFs, and LCR genomic region was sequenced. Results: Fourteen different HPV-6 L1-LCR-E5a-E5b genomic variants were identified among 18 patients with concurrent multiple AGW. In 17 out of 18 patients, a single identical HPV-6 L1-E5a-E5b-LCR genomic variant was identified in all concurrent multiple AGW collected in an individual patient. Co-infection with two different HPV-6 genomic variants was identified in one patient. Discussion: The presence of an identical HPV genomic variant in all concurrently present multiple AGW within an individual patient supports the hypothesis that the occurrence of multiple concurrent AGW is a consequence of infection with a single HPV-6 genomic variant, rather than infection with multiple genomic variants of HPV-6.
Jezik:
Angleški jezik
Ključne besede:
HPV-6 virus
,
anogenitalne bradavice
,
genetika
Vrsta gradiva:
Delo ni kategorizirano (r6)
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Leto izida:
2013
Št. strani:
str. 31-33
Številčenje:
Vol. 22, no. 1
UDK:
578
ISSN pri članku:
1318-4458
DOI:
10.2478/v10162-012-0028-x
COBISS.SI-ID:
30628313
Število ogledov:
666
Število prenosov:
180
Metapodatki:
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(0 glasov)
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Gradivo je del revije
Naslov:
Acta dermatovenerologica Alpina, Panonnica et Adriatica
Skrajšan naslov:
Acta dermatovenerolog. Alp. Panon. Adriat.
Založnik:
Slovene Welding Society
ISSN:
1318-4458
COBISS.SI-ID:
31649024
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