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Genetic diversity of HPV-6 in concurrent multiple anogenital warts
Fujs Komloš, Kristina (Avtor), Košorok, Pavle (Avtor), Kocjan, Boštjan (Avtor), Poljak, Mario (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.acta-apa.org/ Novo okno

Izvleček
Introduction: Anogenital warts (AGW) are the most common benign tumors in the anogenital area. They are etiologically associated with alpha human papillomaviruses (HPV), in more than 90% of cases with HPV-6 and HPV-11. AGW frequently displays a multifocal and multicentric appearance. However, it is not clear whether the occurrence of multiple AGW in a particular patient is a consequence of infection with single or multiple HPV genomic variants of a given HPV genotype. Methods: Forty-five HPV-6 isolates from fresh-frozen AGW tissue specimens, obtained from 18 patients with concurrent multiple AGW, were included. The entire HPV-6 L1, E5a, E5b ORFs, and LCR genomic region was sequenced. Results: Fourteen different HPV-6 L1-LCR-E5a-E5b genomic variants were identified among 18 patients with concurrent multiple AGW. In 17 out of 18 patients, a single identical HPV-6 L1-E5a-E5b-LCR genomic variant was identified in all concurrent multiple AGW collected in an individual patient. Co-infection with two different HPV-6 genomic variants was identified in one patient. Discussion: The presence of an identical HPV genomic variant in all concurrently present multiple AGW within an individual patient supports the hypothesis that the occurrence of multiple concurrent AGW is a consequence of infection with a single HPV-6 genomic variant, rather than infection with multiple genomic variants of HPV-6.

Jezik:Angleški jezik
Ključne besede:HPV-6 virus, anogenitalne bradavice, genetika
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2013
Št. strani:str. 31-33
Številčenje:Vol. 22, no. 1
UDK:578
ISSN pri članku:1318-4458
DOI:10.2478/v10162-012-0028-x Povezava se odpre v novem oknu
COBISS.SI-ID:30628313 Povezava se odpre v novem oknu
Število ogledov:407
Število prenosov:113
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Acta dermatovenerologica Alpina, Panonnica et Adriatica
Skrajšan naslov:Acta dermatovenerolog. Alp. Panon. Adriat.
Založnik:Slovene Welding Society
ISSN:1318-4458
COBISS.SI-ID:31649024 Novo okno

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