Liponucleoside thin films : the special behaviour of guanosine
Čoga, Lucija (Author), Ilc, Tina (Author), Devetak, Miha (Author), Masiero, Stefano (Author), Gramigna, Lucia (Author), Spada, Gian Piero (Author), Drevenšek Olenik, Irena (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0927776512005760 This link opens in a new window

We performed a comparative study of self-assembling properties of liponucleoside materials containing different nucleobases in their hydrophilic headgroups, but possessing the same type of lipophilic moiety in their hydrophobic tails. Surface pressure versus area isotherms ([pi](A)) of monolayers formed at the air-water interface show that guanine-based materials form stable monolayer films exhibiting a profound first order phase transition from the liquid expanded to the condensed phase. Materials based on other nucleobases form less stable films exhibiting a liquid-like behaviour. Analysis of surface structures of Langmuir films with Brewster angle microscopy (BAM) and of Langmuir-Blodgett (LB) films deposited on mica surface by atomic force microscopy (AFM) confirms surface organization as resolved from the isotherms. The specific behaviour of molecules with a guanine head group is attributed to their optimal hydrophilic/hydrophobic balance, which is associated with the low water solubility of guanine derivatives.

Keywords:nucleolipids, surface assembly, Langmuir-Blodgett films
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FMF - Faculty of Mathematics and Physics
Number of pages:str. 45-51
Numbering:Vol. 103
ISSN on article:0927-7765
COBISS.SI-ID:2512484 Link is opened in a new window
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Record is a part of a journal

Title:Colloids and surfaces
Shortened title:Colloids surf., B Biointerfaces
COBISS.SI-ID:15329029 This link opens in a new window

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