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Oxidative stress in schizophrenia patients treated with long-acting haloperidol decanoate
Bošković, Marija (Avtor), Grabnar, Iztok (Avtor), Terzič, Tea (Avtor), Kores-Plesničar, Blanka (Avtor), Vovk, Tomaž (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0165178113004952 Povezava se odpre v novem oknu

Izvleček
In this study the role of oxidative stress in schizophrenia was investigated by evaluating the relationship of oxidative stress markers with neurochemistry, psychopathology, and extrapyramidal symptoms. Antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and concentrations of malondialdehyde, protein carbonyls, nitrite, nitrate, glutathione, dopamine, noradrenaline, adrenaline,and serotonin were measured in 52 outpatients with DSM-IV diagnosis of schizophrenia treated with haloperidol decanoate. Psychopathology and extrapyramidal symptoms were assessed by positive and negative syndrome scale, global assessment of functioning, abnormal involuntary movement scale, Simpson Angus scale, and Barnes akathisia rating scale. Haloperidol dose was positively correlated with plasma protein carbonyls. Longer duration of illness was associated with decreased levels of glutathione peroxidase. Increased activity of superoxide dismutase was associated with increased levels of catalase, glutathione peroxidase, glutathione reductase and reduced glutathione, and decreased concentration of malondialdehyde, indicating joint action of various antioxidative systems. Increased levels of nitrite and nor adrenaline were associated with decreased level of malondialdehyde. Akathisia was greater in patients with decreased catalase activity, indicating involvement of impaired antioxidant defense in developing extrapyramidal symptoms. These results confirm the hypothesis that oxidative stress is involved in pathophysiology of schizophrenia and severity of extrapyramidal symptoms.

Jezik:Angleški jezik
Ključne besede:shizofrenija, oksidativni stres, psihopatologija shizofrenije, nevrotransmiterji, haloperidol
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 761-768
Številčenje:Vol. 210, iss. 3
UDK:615.214.2:616.89
ISSN pri članku:0165-1781
DOI:10.1016/j.psychres.2013.08.035 Povezava se odpre v novem oknu
COBISS.SI-ID:3507825 Povezava se odpre v novem oknu
Število ogledov:673
Število prenosov:142
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Psychiatry research
Skrajšan naslov:Psychiatry res.
Založnik:Elsevier/North-Holland
ISSN:0165-1781
COBISS.SI-ID:12302297 Povezava se odpre v novem oknu

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