Oxidative stress in schizophrenia patients treated with long-acting haloperidol decanoate
Bošković, Marija (Author), Grabnar, Iztok (Author), Terzič, Tea (Author), Kores-Plesničar, Blanka (Author), Vovk, Tomaž (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0165178113004952 This link opens in a new window

In this study the role of oxidative stress in schizophrenia was investigated by evaluating the relationship of oxidative stress markers with neurochemistry, psychopathology, and extrapyramidal symptoms. Antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and concentrations of malondialdehyde, protein carbonyls, nitrite, nitrate, glutathione, dopamine, noradrenaline, adrenaline,and serotonin were measured in 52 outpatients with DSM-IV diagnosis of schizophrenia treated with haloperidol decanoate. Psychopathology and extrapyramidal symptoms were assessed by positive and negative syndrome scale, global assessment of functioning, abnormal involuntary movement scale, Simpson Angus scale, and Barnes akathisia rating scale. Haloperidol dose was positively correlated with plasma protein carbonyls. Longer duration of illness was associated with decreased levels of glutathione peroxidase. Increased activity of superoxide dismutase was associated with increased levels of catalase, glutathione peroxidase, glutathione reductase and reduced glutathione, and decreased concentration of malondialdehyde, indicating joint action of various antioxidative systems. Increased levels of nitrite and nor adrenaline were associated with decreased level of malondialdehyde. Akathisia was greater in patients with decreased catalase activity, indicating involvement of impaired antioxidant defense in developing extrapyramidal symptoms. These results confirm the hypothesis that oxidative stress is involved in pathophysiology of schizophrenia and severity of extrapyramidal symptoms.

Keywords:shizofrenija, oksidativni stres, psihopatologija shizofrenije, nevrotransmiterji, haloperidol
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 761-768
Numbering:Vol. 210, iss. 3
ISSN on article:0165-1781
DOI:10.1016/j.psychres.2013.08.035 Link is opened in a new window
COBISS.SI-ID:3507825 Link is opened in a new window
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Title:Psychiatry research
Shortened title:Psychiatry res.
COBISS.SI-ID:12302297 This link opens in a new window

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