Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: Pleiotropic evidence from plasma mRNA analyses
Mirjanić-Azarić, Bosa (Author), Rizzo, Manfredi (Author), Sormaz, Ljubomir (Author), Stojanović, Darja (Author), Uletović, Snežana (Author), Sodin-Šemrl, Snežna (Author), Lakota, Katja (Author), Artenjak, Andrej (Author), Marc, Janja (Author), Černe, Darko (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S000991201300283X# This link opens in a new window

OBJECTIVE: Statin pleiotropy is still an evolving concept, and the lack of clarity on this subject is due at least in part to the lack of a definitive biomarker for statin pleiotropy. Using plasma mRNA analysis as a novel research tool for the non-invasive in vivo assessment of gene expression in vascular beds, we hypothesised that atorvastatin lowers the plasma mRNA level from statin pleiotropy-target genes, and the reduction is independent of the reduction of low-density lipoprotein cholesterol (LDL-C). DESIGN AND METHODS: Forty-four patients with stable angina received atorvastatin therapy (20mg/day, 10weeks). Plasma chemokine (C-C motif) ligand 2 (CCL2) and intercellular adhesion molecule-1 (ICAM1) mRNA levels and their protein concentrations (MCP-1, sICAM-1) were analysed before and after the treatment. Plasma vascular adhesion molecule-1 (sVCAM-1) concentrations were also analysed. RESULTS: Atorvastatin lowered plasma mRNA levels (CCL2: -31.76%, p=0.037; ICAM1: -34.09%, p<0.001) and MCP-1 protein concentration (-18.88%, p=0.008) but did not lower sICAM-1 and sVCAM-1 protein concentrations, and the decreases appeared to be independent from the lowering of LDL-C. The plasma mRNA levels correlated with their protein concentrations following statin treatment only. CONCLUSION: Our results significantly strengthen the clinical evidence in support of statin pleiotropy. Furthermore, this unique simultaneous measurement of plasma mRNAs and their protein concentrations offers an advanced non-invasive in vivo assessment of the circulation pathology.

Keywords:atorvastatin, CCL2, ICAM1, mRNA in plasma, pleitropic effects
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 1526-1531
Numbering:Vol. 46, iss. 15
ISSN on article:0009-9120
DOI:10.1016/j.clinbiochem.2013.06.006 Link is opened in a new window
COBISS.SI-ID:3507569 Link is opened in a new window
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Title:Clinical biochemistry
Shortened title:Clin. biochem.
COBISS.SI-ID:22275033 This link opens in a new window

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