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Cinnamic Acid derivatives induce cell cycle arrest in carcinoma cell lines
Sova, Matej (Avtor), Žižak, Željko (Avtor), Stanković, Jelena (Avtor), Prijatelj, Matevž (Avtor), Turk, Samo (Avtor), Juranić, Zorica (Avtor), Mlinarič-Raščan, Irena (Avtor), Gobec, Stanislav (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.eurekaselect.com/111596/article Novo okno

Izvleček
Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of theplant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC50s between 42 and 166 ŽM) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol oramine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.

Jezik:Angleški jezik
Ključne besede:derivati cimetne kisline, zdravila, zdravljenje raka, raziskave, citotoksičnost zdravil, antineoplastiki
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 633-641
Številčenje:Vol. 9, iss. 5
UDK:615.2:616-006
ISSN pri članku:1573-4064
DOI:10.2174/1573406411309050002 Povezava se odpre v novem oknu
COBISS.SI-ID:3492977 Povezava se odpre v novem oknu
Število ogledov:360
Število prenosov:162
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:Medicinal chemistry
Založnik:Bentham Science Publishers
ISSN:1573-4064
COBISS.SI-ID:3491441 Novo okno

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