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Cinnamic Acid derivatives induce cell cycle arrest in carcinoma cell lines
Sova, Matej (Author), Žižak, Željko (Author), Stanković, Jelena (Author), Prijatelj, Matevž (Author), Turk, Samo (Author), Juranić, Zorica (Author), Mlinarič-Raščan, Irena (Author), Gobec, Stanislav (Author)

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Abstract
Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of theplant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC50s between 42 and 166 ŽM) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol oramine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.

Language:English
Keywords:derivati cimetne kisline, zdravila, zdravljenje raka, raziskave, citotoksičnost zdravil, antineoplastiki
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2013
Number of pages:str. 633-641
Numbering:Vol. 9, iss. 5
UDC:615.2:616-006
ISSN on article:1573-4064
DOI:10.2174/1573406411309050002 Link is opened in a new window
COBISS.SI-ID:3492977 Link is opened in a new window
Views:381
Downloads:168
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Record is a part of a journal

Title:Medicinal chemistry
Publisher:Bentham Science Publishers
ISSN:1573-4064
COBISS.SI-ID:3491441 This link opens in a new window

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