The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers
Janković, Biljana (Author), Pelipenko, Jan (Author), Škarabot, Miha (Author), Muševič, Igor (Author), Kristl, Julijana (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0378517313006030# This link opens in a new window

This paper especially highlights the finding that the mechanical properties ofpolymeric nanofibers can be tuned by changing the fiber size as well as the composition. For this purpose, the bending Young's modulus was determined using atomic force microscope by involving single-material (polyvinyl alcohol (PVA), polyethylene oxide (PEO 400K)) and composite nanofibers (polyvinyl alcohol/hyaluronic acid (PVA/HA), polyethylene oxide/chitosan (PEO 400K/CS)). The mechanical property, namely the bending Young's modulus, increases as the diameter of the fibers decreases from the bulk down to the nanometer regime (less than 200 nm). The ranking of increasing stiffness according to the AFM measurements of the three-point beam bending test are in agreement, and can beranked: PEO 400K < PVA/HA Ž PVA < PEO < 400K/CS. According to our results, CS-based nanofibers are the stiffest (15 GPa) and the most resilient to erosion in an aqueous medium. Consequently, they possess the most appropriate attributes for bone, tendon, and cartilage tissue scaffold engineering. Nanofibers based on PVA (6 GPa) and PEO (3 GPa) are more elastic (a smaller bending Young's modulus) and therefore are the most suitable for skin and wound tissue scaffolds.

Keywords:electrospinning, nanofiber, atomic force microscopy, elasticity
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 338-347
Numbering:Vol. 455, iss. 1/2
ISSN on article:0378-5173
DOI:10.1016/j.ijpharm.2013.06.083 Link is opened in a new window
COBISS.SI-ID:3491953 Link is opened in a new window
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Record is a part of a journal

Title:International journal of pharmaceutics
Shortened title:Int. j. pharm.
COBISS.SI-ID:3087631 This link opens in a new window

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