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Consolidation trend design based on Young's modulus of clarithromycin single crystals
Janković, Biljana (Author), Škarabot, Miha (Author), Lavrič, Zoran (Author), German Ilić, Ilija (Author), Muševič, Igor (Author), Srčič, Stanko (Author), Planinšek, Odon (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0378517313006157# This link opens in a new window

Abstract
The key aim of this study was to determine single mechanical properties of clarithromycin polymorphic forms in order to select some of them as more suitable for the tableting process. For this purpose, AFM single-point nanoindentation was used. The Young's moduli of clarithromycin polymorphs were substantially different, which was consistent with the structural variations in their packing motifs. The presence of the adjacent layers, which can easily slide over each other due to the low energy barrier (the lowest Young's modulus was 0.25 GPa) resulted in better bulk compressibility (the highest Heckel coefficient) of clarithromycin Form I. We also addressed the importance of tip geometry screening because the stress during the force mode often results in tip apex fracture. Even the initial manufacture of the diamond-coated tips can result in defects such as double-apex tips.

Language:English
Keywords:polimorfizem, klaritromicin, mikroskop na atomsko silo, Youngov model
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2013
Number of pages:str. 324-332
Numbering:Vol. 454, iss. 1
UDC:543
ISSN on article:0378-5173
DOI:10.1016/j.ijpharm.2013.07.011 Link is opened in a new window
COBISS.SI-ID:3491697 Link is opened in a new window
Views:959
Downloads:234
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Record is a part of a journal

Title:International journal of pharmaceutics
Shortened title:Int. j. pharm.
Publisher:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 This link opens in a new window

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