Lecithin based lamellar liquid crystals as a physiologically acceptable dermal delivery system for ascorbyl palmitate
Gosenca Matjaž, Mirjam (Author), Bešter-Rogač, Marija (Author), Gašperlin, Mirjana (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0928098713001723# This link opens in a new window

Liquid crystalline systems with a lamellar structure have been extensively studied as dermal delivery systems. Ascorbyl palmitate (AP) is one of the most studied and used ascorbic acid derivatives and is employed as an antioxidant to prevent skin aging. The aim of this study was to develop and characterize skin-compliant dermal delivery systems with a liquid crystalline structure for AP. First, a pseudoternary phase diagram was constructed using Tween 80/lecithin/isopropyl myristate/water at a Tween 80/lecithin mass ratio of 1/1, and the region of lamellar liquid crystals was identified. Second, selected unloaded and AP-loaded lamellar liquid crystal systems were physicochemically characterized with polarizing optical microscopy, small-angle X-ray scattering, differential scanning calorimetry, and rheology techniques. The interlayer spacing and rheological parameters differ regarding quantitative composition, whereas the microstructure of the lamellar phase was affected by the AP incorporation, resulting either in additional micellar structures (at 25 and 32°C) or being completely destroyed at higher temperature (37°C). After this, the study was oriented towards in vitro cytotoxicity evaluation of lamellar liquid crystal systems on a keratinocyte cell line. The results suggest that the lamellar liquid crystals that were developed could be used as a physiologically acceptable dermal delivery system.

Keywords:pseudoternary phase diagrams, lamellar liquid crystalline phase, ascorbyl palmitate, keratinocytes, cytotoxicity
Work type:Not categorized (r6)
Tipology:1.08 - Published Scientific Conference Contribution
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 114-122
Numbering:Vol. 50, issue 1
ISSN on article:0928-0987
DOI:10.1016/j.ejps.2013.04.029 Link is opened in a new window
COBISS.SI-ID:3440753 Link is opened in a new window
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Record is a part of a proceedings

Title:Emerging Nanopharmaceuticals for Non-parenteral Application Routes
COBISS.SI-ID:3497073 This link opens in a new window

Record is a part of a journal

Title:European Journal of Pharmaceutical Sciences
Shortened title:Eur. j. pharm. sci.
COBISS.SI-ID:17553413 This link opens in a new window

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