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Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight
Kippler, Maria (Avtor), Engström, Karin (Avtor), Jurković Mlakar, Simona (Avtor), Bottai, Matteo (Avtor), Ahmed, Sultan (Avtor), Hossain, Mohammad Bakhtiar (Avtor), Raqib, Rubhana (Avtor), Vahter, Marie (Avtor), Broberg, Karin (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.landesbioscience.com/journals/epigenetics/article/24401/ Novo okno

Izvleček
Dietary cadmium exposure was recently found to alter DNA methylation in adults, but data on effects early in life are lacking. Our objective was to evaluate associations between prenatal cadmium exposure, DNA methylation and birth weight. In total 127 mother-child pairs from rural Bangladesh were studied. For comparison, we included 56 children at 4.5 y. Cadmium concentrations in mothersʼ blood (gestational week 14) and childrenʼs urine were measured by ICPMS. Global DNA methylation was analyzed by Infinium Human Methylation 450K BeadChip in cord blood and childrenʼs blood. Maternal cadmium exposure was associated with cord blood DNA methylation (p-value < 10-16). The association was markedly sex-specific. In boys, 96% of the top 500 CpG sites showed positive correlations (rS-values > 0.50), whereas most associations in girls were inverse; only 29% were positive (rS > 0.45). In girls we found overrepresentation of methylation changes in genes associated with organ development, morphology and mineralization of bone, whereas changes in boys were found in cell death-related genes. Several individual CpG sites that were positively associated with cadmium were inversely correlated with birth weight, although none statistically significant after correction for multiple comparisons. The associations were, however, fairly robust in multivariable-adjusted linear regression models. We identified CpG sites that were significantly associated with cadmium exposure in both newborns and 4.5-y-old children. In conclusion, cadmium exposure in early life appears to alter DNA methylation differently in girls and boys. This is consistent with previous findings of sex-specific cadmium toxicity. Cadmium-related changes inmethylation were also related to lower birth weight.

Jezik:Angleški jezik
Ključne besede:450K, CpG, epigenetic, fetal development, gender, gene-environment interaction, growth
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 494-503
Številčenje:Vol. 8, no. 5
UDK:575.17
ISSN pri članku:1559-2294
COBISS.SI-ID:3431793 Povezava se odpre v novem oknu
Število ogledov:414
Število prenosov:142
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Epigenetics
Založnik:Landes Bioscience
ISSN:1559-2294
COBISS.SI-ID:3431537 Novo okno

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