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Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin: Design and in vitro evaluation
Radivojša Matanović, Maja (Avtor), Grabnar, Iztok (Avtor), Ahlin Grabnar, Pegi (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0928098713000973# Povezava se odpre v novem oknu

Izvleček
In situ forming systems including thermoreversible hydrogels, which undergo sol-gel transition upon an increase in temperature have been used for various biomedical applications. Heparins are the standard of anticoagulation in the prophylaxis and treatment of deep vein thrombosis and pulmonary embolism. Bothconditions require long-lasting treatment with frequent subcutaneous administrations of heparin. The objective of this study was to prepare and evaluate in situ forming gel systems designed by combination of two poloxamers(P407 and P188) and hydroxypropylmethylcellulose (HPMC) for prolonged release of heparin. Thermoreversible hydrogels were prepared with heparin solution and dispersion of heparin/chitosan nanocomplexes. Nanocomplexes formed by self-assembly of heparin with chitosan at various massratios were thoroughly characterized. A heparin/chitosan mass ratio of 1:1with pH 5.20 was the most appropriate for preparation of small, homogenous and stable nanocomplexes (mean diameter 123 nm; polydispersity index 0.22 and zeta potential + 35.5 mV). Thermoreversible hydrogels were evaluated by gelation temperature, viscosity over the temperature range 20-40 °C, rate of hydrogel dissolution, and heparin release in vitro. The addition of P188 to P407 gel formulations resulted in an increase in gelation temperature, decrease in viscosity at room temperature and faster gel dissolution. The opposite effects were observed with formulations containing HPMC which demonstrated 18-day-long gel dissolution and complete heparin release in 9 days from gels containing heparin solution. Considerable prolongation of heparin release was achieved with incorporation of heparin/chitosan nanocomplexes into the gelling systems. It may be concluded that with poloxamer mixtures at specific concentrations, addition of HPMC and use of heparin/chitosan nanocomplexes dispersions, thermoreversible formulations for prolonged subcutaneous release of heparin are feasible.

Jezik:Angleški jezik
Ključne besede:in situ forming systems, thermoreversible hydrogels, heparin, chitosan nanocomplexes, prolonged release, subcutaneous delivery
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 93-101
Številčenje:Vol. 50, iss. 1
UDK:542+615.011
ISSN pri članku:0928-0987
DOI:10.1016/j.ejps.2013.03.002 Povezava se odpre v novem oknu
COBISS.SI-ID:3418737 Povezava se odpre v novem oknu
Število ogledov:623
Število prenosov:209
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del zbornika

Naslov:Emerging Nanopharmaceuticals for Non-parenteral Application Routes
COBISS.SI-ID:3497073 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:European Journal of Pharmaceutical Sciences
Skrajšan naslov:Eur. j. pharm. sci.
Založnik:Elsevier
ISSN:0928-0987
COBISS.SI-ID:17553413 Povezava se odpre v novem oknu

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