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Deformation properties of pharmaceutical excipients determined using an in-dieand out-die method
Ilić, Ilija (Avtor), Janković, Biljana (Avtor), Šibanc, Rok (Avtor), Dreu, Rok (Avtor), Srčič, Stanko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S037851731300135X Novo okno

Izvleček
This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (w/w) filler, the rest consisted of dry binder and an anti adhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die methodŽcomparison revealed that the differences are a consequence of the material's elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material's mechanical properties for better elucidation of deformation mechanisms.

Jezik:Angleški jezik
Ključne besede:Heckell, Walker, in-die, out-die, nanoindentation, deformation
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 6-15
Številčenje:Vol. 446, no. 1-2
UDK:541.182+66.063.6+615.453
ISSN pri članku:0378-5173
COBISS.SI-ID:3407985 Povezava se odpre v novem oknu
Število ogledov:551
Število prenosov:118
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Ključne besede:trdne farmacevtske oblike, dostavni sistemi, tablete, pomožne snovi, Hecklov model, Walker model

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