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N-methyl-D-aspartate-receptor antibodies, S100B protein, and neuron-specific enolase before and after cardiac surgery: association with ischemic brain injury and erythropoetin prophylaxis
Skitek, Milan (Avtor), Jerin, Aleš (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://labmed.ascpjournals.org/content/44/1.toc Povezava se odpre v novem oknu

Izvleček
Objective: To evaluate biomarkers of acute ischemic brain injury after surgical revascularization of the heart with the use of the heart-lung machine(ie, cardiopulmonary bypass [CPB]). Methods Twenty consecutive patients were divided into 2 groups: the first 10 patients received a potential neuro protective human recombinant erythropoietin and the remaining 10 comprised the control group. Neurological complications were monitored by measuring serum concentrations of N-methyl-D-aspartate (NMDA)-receptor antibodies (NR2Ab), S100B protein, and neuron-specific enolase (NSE) before and during the first 5 days after surgery, comparing the neurological outcome with the results of MRI examinations. Results The results from the erythropoietin-treated group and the control group were similar, with a significant difference shown for the postoperative NSE. Comparison of serum concentrations of the biomarkers of 16 patients without brain ischemia and 4 patients with acute ischemia displayed significant differences for only postoperative NR2Ab, regardless if the patient received erythropoietin therapy. Conclusions The analysis of NR2Ab serum concentrations might be useful for monitoring neuroprotective stroke treatment; however, further studies are required to investigate its role in acute ischemic brain injury.

Jezik:Angleški jezik
Ključne besede:biomarkerji, ishemične okvare možgan, srčne operacije, nevrologija, eritropoetin
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 56-62
Številčenje:Vol. 44, no. 1
UDK:616.831-071-085+617-089
ISSN pri članku:0007-5027
DOI:10.1309/LMZI8CEAATHRXR74 Povezava se odpre v novem oknu
COBISS.SI-ID:3402609 Povezava se odpre v novem oknu
Število ogledov:411
Število prenosov:172
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Laboratory medicine
Skrajšan naslov:Lab. med.
Založnik:American Society of Clinical Pathologists
ISSN:0007-5027
COBISS.SI-ID:512276249 Povezava se odpre v novem oknu

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