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Osteoarthritic versus osteoporotic bone and intra-skeletal variations in normal bone: Evaluation with [micro]CT and bone histomorphometry
Zupan, Janja (Avtor), van't Hof, Rob J. (Avtor), Vindišar, Franci (Avtor), Haring, Gregor (Avtor), Trebše, Rihard (Avtor), Komadina, Radko (Avtor), Marc, Janja (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://onlinelibrary.wiley.com/doi/10.1002/jor.22318/pdf Povezava se odpre v novem oknu

Izvleček
Several studies have shown that in contrast to osteoporosis (OP), osteoarthritis (OA) is characterized by high bone mineral density (BMD). Bone strength not only depends on mineral content as determined by dual X-ray absorptiometry (DXA), but also on bone microarchitecture. We studied intertrochanteric bone from normal controls and OA and OP patients by bone histomorphometry (BHM) and microcomputed tomography (ŽCT) as well as DXA in order to first, test the differences between OA and OP comparing both groups to healthy controls, second, to assess variations between three different skeletal sites in controls and third, to determine the level of agreement between microCT, BHM, and DXA. Analysis was performed on 115 samples from OA and OP patients, and controls. We found significant differences between OA and OP samples in structural parameters and in the osteoid fraction (p<0.05). The majority of the intra-skeletal differences were shown between lumbar spine andfemoral head samples (p<0.05). Significant agreements were found between microCT and BHM and DXA (r=0.32-0.45, p<0.05). Our findings suggest differences in intertrochanteric bone between OA and OP, the age-related intra-skeletal variations and a correlation between microscopic and macroscopic bone evaluation methods.

Jezik:Angleški jezik
Ključne besede:osteoartritis, osteporoza, histomorfometrija, zdravljenje osteoporoze
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 1059-1066
Številčenje:Vol. 31, iss. 7
UDK:616.7-08
ISSN pri članku:0736-0266
DOI:10.1002/jor.22318 Povezava se odpre v novem oknu
COBISS.SI-ID:3393137 Povezava se odpre v novem oknu
Število ogledov:333
Število prenosov:144
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Journal of orthopaedic research
Skrajšan naslov:J. orthop. res.
Založnik:Elsevier Science
ISSN:0736-0266
COBISS.SI-ID:3161684 Povezava se odpre v novem oknu

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