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Iron regulated surface determinant B (IsdB) promotes Staphylococcus aureus adherence to and internalization by non-phagocytic human cells
Zapotoczna, Marta (Avtor), Jevnikar, Zala (Avtor), Miajlović, Helen (Avtor), Kos, Janko (Avtor), Foster, Timothy J. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://onlinelibrary.wiley.com/doi/10.1111/cmi.12097/pdf Novo okno

Izvleček
Staphylococcus aureus is a human pathogen that causes invasive and recurring infections. The ability to internalize into and persist within host cells is thought to contribute to infection. Here we report a novel role for the well characterized iron regulated surface determinant B (IsdB) protein which we have shown can promote adhesion of 293T, HeLa cells and platelets to immobilized bacteria independently of its ability to bind haemoglobin. IsdB bound to the active form of the platelet integrin ŽIIbŽ3, both on platelets and when the integrin was expressed ectopically in CHO cells. IsdB also promoted bacterial invasion into human cells. This was clearly demonstrated with bacteria lacking fibronectin-binding proteins (FnBPs), which are known to promote invasion in the presence of fibronectin, However, IsdB also contributed significantly to invasion by cells expressing FnBPs in the presence of serum. Thus IsdB appears to be able to interact with the broader family of integrins that bind ligands with the RGD motif and to act as a back up mechanism to promote interactions with mammalian cells.

Jezik:Angleški jezik
Ključne besede:Staphylococcus aureus, Isd proteins, S. aureus invasion, S. aureus adherence
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 1026-1041
Številčenje:Vol. 15, no. 6
UDK:616.9-08
ISSN pri članku:1462-5814
DOI:10.1111/cmi.12097 Povezava se odpre v novem oknu
COBISS.SI-ID:3379569 Povezava se odpre v novem oknu
Število ogledov:608
Število prenosov:157
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Cellular microbiology
Skrajšan naslov:Cell. microbiol.
Založnik:Blackwell Science
ISSN:1462-5814
COBISS.SI-ID:554773 Novo okno

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