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Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes
Loch, Christian (Avtor), Žakelj, Simon (Avtor), Kristl, Albin (Avtor), Nagel, Stefan (Avtor), Guthoff, Rudolf F. (Avtor), Weitschies, Werner (Avtor), Seidlitz, Anne (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0928098712002345 Povezava se odpre v novem oknu

Izvleček
To treat ophthalmic diseases like glaucoma or inflammatory disorders topically applied ophthalmic formulations such as eye drops are usually used. In addition, novel ophthalmic implants releasing drug substances locally into different parts of the eye are available today. In the work presented here, the permeability coefficients of selected drugs (ciprofloxacin hydrochloride, lidocaine hydrochloride, timolol maleate) for ophthalmic tissues were determined using side-by-side diffusion chambers (so-called Ussing chambers). Sclera, conjunctiva, cornea, choroidea-retina-complex and a complex of conjunctiva-sclera-choroidea-retina were excised from fresh porcine, rabbit and bovine eyes. In the porcine eye tissues the highest Papp values were obtained for conjunctiva with the exception of lidocaine. Therefore, it can beestimated that a certain amount of drug diffuses or is transported through conjunctiva after application. The Papp values for sclera were also higher than those for cornea and even more, the surface area of sclera which is available for drug absorption is much larger than that of cornea when applying an implant. The obtained permeability coefficients for sclera and conjunctiva indicate that the administration of periocular implants can be an alternative to topically applied formulations. The complexes of the tissues were a significantly (p < 0.01) stronger barrier to the investigated substances than the separated tissues. Distinct differences in permeability coefficients between the investigated animal tissues were observed. Overall the highest Papp values for all mounted tissues were obtained with the rabbit,followed by porcine and bovine eyes. Because of these distinct interspecies differences one must be very careful when selecting the proper animal model for the permeability experiments.

Jezik:Angleški jezik
Ključne besede:ophthalmic tissues, ophthalmic implants, permeability coefficient, side-by-side diffusion chambers, ussing chamber
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 131-138
Številčenje:Vol. 47, no. 1
UDK:615.011.2+617.7
ISSN pri članku:0928-0987
DOI:10.1016/j.ejps.2012.05.007 Povezava se odpre v novem oknu
COBISS.SI-ID:3370353 Povezava se odpre v novem oknu
Število ogledov:515
Število prenosov:166
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:European Journal of Pharmaceutical Sciences
Skrajšan naslov:Eur. j. pharm. sci.
Založnik:Elsevier
ISSN:0928-0987
COBISS.SI-ID:17553413 Povezava se odpre v novem oknu

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