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Excretion profile of glycyrrhizin metabolite in human urine
Kočevar Glavač, Nina (Avtor), Kreft, Samo (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0308814611012350 Novo okno

Izvleček
Glycyrrhizin is the main pharmacologically active component in licorice. Long term consumption of higher amounts of glycyrrhizin results in serious side effects (pseudoaldosteronism) caused by the glycyrrhizin metabolite 3b-monoglucuronyl-18b-glycyrrhetinic acid (3-MGA). The aim of this study was to determine urine excretion profile of 3-MGA. Six healthy volunteers ingested 600 mg of glycyrrhizin. In the first experimental period, glycyrrhizin was ingested in the morning and in the second experimental period, which followed after 2 weeks, glycyrrhizin was ingested in the evening. Results showed that the amount of excreted 18-MGA in urine was 1425.9-3147.8 lg, which corresponds to 0.31-0.67% of the ingested dose. Maximum elimination rates were 31.52-209.47 lg/h. There were no significant differences in the amount of excreted 3-MGA as well as in elimination rates of3-MGA when glycyrrhizin was ingested in the morning or evening, respectively. These results provide some important clinical data on glycyrrhizin metabolism.

Jezik:Angleški jezik
Ključne besede:glycyrrhizin, glycyrrhetinic acid, HPLC, licorice, urine
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 305-308
Številčenje:Vol. 131, iss. 1
UDK:633.88+581.19
ISSN pri članku:0308-8146
DOI:10.1016/j.foodchem.2011.08.081 Povezava se odpre v novem oknu
COBISS.SI-ID:3299953 Povezava se odpre v novem oknu
Število ogledov:449
Število prenosov:156
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:Food chemistry
Skrajšan naslov:Food chem.
Založnik:Applied Science Publishers
ISSN:0308-8146
COBISS.SI-ID:6385415 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Ključne besede:glicirizin, glicirizinska kislina, HPLC, urin, sladki koren

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