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Microencapsulation of self-microemulsifying systems: optimization of shell-formation phase and hardening process
Zvonar Pobirk, Alenka (Avtor), Bolko, Katarina (Avtor), Gašperlin, Mirjana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0378517312008083# Povezava se odpre v novem oknu

Izvleček
The preparation of microcapsules with a self-microemulsifying system (SMES) core using a vibrating nozzle technology was improved with regard to process reproducibility and core phase retention. The microcapsule shell was optimized for composition of the alginate-pectin (A/P) ratio and hydrophilic filling agent content. The best-shaped microcapsules with highest encapsulation efficiency for furosemide-loaded SMES were obtained from the shell-formation phase with an A/P ratio of 25:75, containing 10% lactose, which was hardened through a one-step process. Fluid bed-dried microcapsules were examined for their release characteristics and swelling behavior of the polymeric matrix. Incorporation of hydrophilic filling agents in the shell-formation phase was shown to be successful in limiting the leakage of the core phase during the microcapsule production and drying processes. Moreover, the addition of different fillers also allows the drug release profile from Ca-alginate/pectinate microcapsules with a self-microemulsifying core to be modified.

Jezik:Angleški jezik
Ključne besede:mikrokapsule, alginat, pektin, sproščanje zdravil
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 294-302
Številčenje:Vol. 437, no. 1-2
UDK:661.12+66.09
ISSN pri članku:0378-5173
DOI:10.1016/j.ijpharm.2012.08.013 Povezava se odpre v novem oknu
COBISS.SI-ID:3292017 Povezava se odpre v novem oknu
Število ogledov:488
Število prenosov:168
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Povezava se odpre v novem oknu

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