izpis_h1_title_alt

Assessment of gene-by-sex interaction effect on bone mineral density
Liu, Ching-Ti (Avtor), Estrada, Karol (Avtor), Yerges-Armstrong, L. (Avtor), Amin, Najaf (Avtor), Evangelou, Evangelous (Avtor), Li, Guo (Avtor), Mencej Bedrač, Simona (Avtor), Marc, Janja (Avtor), Preželj, Janez (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://onlinelibrary.wiley.com/doi/10.1002/jbmr.1679/pdf Novo okno

Izvleček
BACKGROUND: Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed eQTL analysis and bioinformatics network analysis. METHODS: We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction onlumbar spine (LS-) and femoral neck (FN-) BMD, in 25,353 individuals from eight cohorts. In a second stage, we followed up the 12 top SNPs (P<1X10(-5) ) in an additional set of 24,763 individuals. Gene-by-sex interaction and sex-specific effects were examined in these 12 SNPs. RESULTS:We detected one novel genome-wide significant interaction associated with LS-BMD at the Chr3p26.1-p25.1 locus, near the GRM7 gene (male effect=0.02 & p-valueŽ=3.0X10(-5) ; female effect=-0.007 & p-value=3.3X10(-2) ) and eleven suggestive loci associated with either FN-or LS-BMD in discovery cohorts. However, there was no evidence for genome-wide significant (P<5X10(-8) ) gene-by-sex interaction in the joint analysis of discovery and replication cohorts. CONCLUSION: Despite the large collaborative effort, no genome-wide significant evidence for gene-by-sex interaction was found influencing BMD variation in this screen of autosomal markers. If they exist, gene-by-sex interactions for BMD probably have weak effects, accounting for less than 0.08% of the variation in these traits per implicated SNP.

Jezik:Angleški jezik
Ključne besede:gene-by-sex, interaction, BMD, association, aging
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 2051-2064
Številčenje:Vol. 27, issue 10
UDK:577.2
ISSN pri članku:0884-0431
DOI:10.1002/jbmr.1679 Povezava se odpre v novem oknu
COBISS.SI-ID:3286641 Povezava se odpre v novem oknu
Število ogledov:418
Število prenosov:165
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na: Bookmark and Share

Gradivo je del revije

Naslov:Journal of bone and mineral research
Skrajšan naslov:J. bone miner. res.
Založnik:Mary Ann Liebert, Inc.
ISSN:0884-0431
COBISS.SI-ID:7621593 Novo okno

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj