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Encapsulation of natural antioxidant resveratrol in liposomes
Isailović, Bojana D. (Avtor), Kostić, Ivana T. (Avtor), Zvonar Pobirk, Alenka (Avtor), Đorđević, Verica B. (Avtor), Gašperlin, Mirjana (Avtor), Nedović, Viktor (Avtor), Bugarski, Branko M. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://cefood2012.rs/ Novo okno

Izvleček
Liposomes have been shown to be suitable systems for encapsulation and preserving the health-beneficial properties of a wide range of biological active ingredients such as resveratrol (RSV). The aim of this study was to encapsulate RSV in liposomes, with a goal to achieve the extended release and improved stability of RSV. Multilameral liposomes were prepared by means of two different methods: thin film method (TF) and proliposome method (PRO). In both methods, the ratio between added RSV and phospolipon 90G (P90G) was 1:20 w/w. Extrusion and sonication were applied in order to obtain unilameral liposomes. Both methods were efficient in capturing RSV within the microparticles, thus encapsulation efficiency had high values (92,9% in case of TF and 97,4% in case of PRO). The size reduction of liposomes resulted with particles of the average diameter ranged between 120 and 270 nm. Antioxidative activity was retained at a high level (approximately 95%). Franz diffusion cell was used for release studies and diffusion of RSV was monitored for 6h. According to the results, liposomes appeared to be suitable vehicles for encapsulation of resveratrol where PRO is particularly useful for encapsulation of antioxidants.

Jezik:Angleški jezik
Ključne besede:kapsuliranje, liposomi, resveratrol, študije, sproščanje učinkovin, encapsulation, liposome, resveratrol, release study
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:Str. 1046-1051
UDK:66.02+542.9
COBISS.SI-ID:3272305 Povezava se odpre v novem oknu
Število ogledov:613
Število prenosov:132
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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