The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials
Janković, Biljana (Author), Ilić, Ilija (Author), Šibanc, Rok (Author), Dreu, Rok (Author), Srčič, Stanko (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0032591012001982 This link opens in a new window

The study's primary goal was to examine the possible use of single particle mechanical properties to estimate the compressibility behaviour of a tablet's excipients during compaction. Nanoindentation was utilised to measure individual mechanical properties (Young's modulus, nanoindentation hardness, energy of elastic and plastic deformation). On the bulk scale, studied excipients' compressibility was determined by Heckel and Walker models. Single particle hardness was found to provide direct information regarding an excipient's plasticity since an excellent correlation was established with the Walker model on the bulk level. A moderate correlation was obtained with the Heckel model due to its lack of fit for brittle materials. The indentation energy on a single level effectively differentiates materials in which plastic deformation dominates from those materials in which brittle fractures prevail. Elastic properties of materials can be successfully predicted by measuring the energy of elastic deformation on a single scale since an excellent correlation was observed with the bulk parameters such as energy of elastic deformation and the tablets' elastic relaxation index. We found that individual mechanical properties of a tablet's excipients greatly control the materials' deformation behaviour during tablet production despite of numerous other processes occurring during compression in the tablet die such as friction, bonding and local mechanical stress.

Keywords:nanotehnologija, Heckel model, Walker model, tablete
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 43-51
Numbering:Vol. 225, July
ISSN on article:0032-5910
DOI:10.1016/j.powtec.2012.03.030 Link is opened in a new window
COBISS.SI-ID:3236721 Link is opened in a new window
Average score:(0 votes)
Your score:Voting is allowed only to logged in users.
AddThis uses cookies that require your consent. Edit consent...

Record is a part of a journal

Title:Powder technology
Shortened title:Powder technol.
Publisher:Elsevier Sequoia
COBISS.SI-ID:6576645 This link opens in a new window

Similar documents

Similar works from RUL:
Similar works from other Slovenian collections:


Leave comment

You have to log in to leave a comment.

Comments (0)
0 - 0 / 0
There are no comments!