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Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold
Ilić, Miloš (Author), Kikelj, Danijel (Author), Ilaš, Janez (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S022352341200075X New window

Abstract
Fluorinated 3,4-dihydro-2H-1,4-benzoxazine derivatives possessing both thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activitieswere prepared as potential dual antithrombotic compounds. Fluorine scan (3-fluorobenzyl, 4-fluorobenzyl, 3,4-difluorobenzyl and 3,5-difluorobenzyl substituted compounds) was performed in order to obtain 6-(carboxymethyl)(3,4-difluorobenzyl) amino compound (9i) as the most potent 0.07 mM, IC50(GP IIb/IIIa)=compound with balanced dual activity (Ki(Thr)+- 0.33

Language:English
Keywords:trombinski inhibitorji, 1, 4 benzooksazini, antagonisti fibrinogenskih receptorjev, ligandi
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2012
Number of pages:str. 255-263
Numbering:Vol. 50, April
UDC:543
ISSN on article:0223-5234
COBISS.SI-ID:3221873 Link is opened in a new window
Views:357
Downloads:177
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Record is a part of a journal

Title:European journal of medicinal chemistry
Shortened title:Eur. j. med. chem.
Publisher:Elsevier
ISSN:0223-5234
COBISS.SI-ID:25429760 New window

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