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Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells
Magister, Špela (Avtor), Obermajer, Nataša (Avtor), Mirković, Bojana (Avtor), Švajger, Urban (Avtor), Renko, Miha (Avtor), Softić, Adaleta (Avtor), Romih, Rok (Avtor), Colbert, Jeff D. (Avtor), Watts, Colin (Avtor), Kos, Janko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/journal/aip/01719335 Povezava se odpre v novem oknu

Izvleček
In dendritic cells (DCs) cysteine cathepsins play a key role in antigen processing, invariant chain (Ii) cleavage and regulation of cell adhesion after maturation stimuli. Cystatin F, a cysteine protease inhibitor, is present in DCs in endosomal/lysosomal vesicles and thus has a potential to modulate cathepsin activity. In immature DCs cystatin F colocalizes with cathepsin S. After induction of DC maturation however, it is translocated intolysosomes and colocalizes with cathepsin L. The inhibitory potential of cystatin F depends on the properties of the monomer. We showed that the full-length monomeric cystatin F was a 12-fold stronger inhibitor of cathepsin S than the N-terminally processed cystatin F, whereas no significant difference in inhibition was observed for cathepsins L, H and X. Therefore, the role of cystatin F in regulating the main cathepsin S function in DCs, i.e. the processing of Ii, may depend on the form of the monomer present in endosomal/lysosomal vesicles. On the other hand, intact and truncated monomeric cystatin F are both potent inhibitors of cathepsin L and it is likely that cystatin F could regulate its activity in maturing, adherent DCs, controlling the processing of procathepsin X, which promotes cell adhesion viaactivation of Mac-1 (CD11b/CD18) integrin receptor.

Jezik:Angleški jezik
Ključne besede:cistatin F, katepsini, dendritične celice, integrinski receptorji
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 391-401
Številčenje:Vol. 91, no. 5
UDK:616-006
ISSN pri članku:0171-9335
DOI:10.1016/j.ejcb.2012.01.001 Povezava se odpre v novem oknu
COBISS.SI-ID:3207025 Povezava se odpre v novem oknu
Število ogledov:535
Število prenosov:166
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:European journal of cell biology
Skrajšan naslov:Eur. j. cell biol.
Založnik:Elsevier, Urban u. Fischer
ISSN:0171-9335
COBISS.SI-ID:25426688 Povezava se odpre v novem oknu

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