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A microwave-assisted nucleophilic substitution reaction on a quinoline system: the synthesis of amino analogues of nitroxoline : Bogdan Štefane ... [et al.]
Štefane, Bogdan (Author), Požgan, Franc (Author), Sosič, Izidor (Author), Gobec, Stanislav (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0040403912002274?v=s5 New window

Abstract
A reliable protocol for the synthesis of a series of 8-amino analogues of pharmacologically interesting nitroxoline (5-nitro-8-hydroxyquinoline) is described. The unprecedented displacement of the cyanomethoxy group of an O-cyanomethylated quinoline derivative by various primary and secondary aminesselectively affords 5-nitroquinolin-8-ylamines in moderate-to-high yields. The reactions were accelerated significantly under microwave conditions in comparison with conventional heating.

Language:English
Keywords:organska kemija, farmakologija, sinteza, sinteze podprte z mikrovalovi, nukleofilna aromatična substitucija, kinoloni, nitroksolini, cianometoksi skupina, quinolones, nitroxoline, cyanomethoxy group, nucleophilic aromatic substitution, microwave-assisted synthesis
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2012
Number of pages:str. 1964-1967
Numbering:Vol. 53, no. 15
UDC:547.831.057:542:615
ISSN on article:0040-4039
DOI:10.1016/j.tetlet.2012.02.017 Link is opened in a new window
COBISS.SI-ID:3200625 Link is opened in a new window
Views:857
Downloads:140
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Record is a part of a journal

Title:Tetrahedron letters
Shortened title:Tetrahedron lett.
Publisher:Pergamon Press
ISSN:0040-4039
COBISS.SI-ID:972815 New window

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