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A "crossomics" study analysing variability of different components in peripheral blood of health caucasoid individuals
Gruden, Kristina (Avtor), Hren, Matjaž (Avtor), Herman, Ana (Avtor), Blejec, Andrej (Avtor), Albrecht, Tanja (Avtor), Selbig, Joachim (Avtor), Bauer, Chris (Avtor), Schuchardt, Jochannes (Avtor), Or-Guil, Michal (Avtor), Zupančič, Klemen (Avtor), Švajger, Urban (Avtor), Štabuc, Borut (Avtor), Ihan, Alojz (Avtor), Kopitar, Andreja Nataša (Avtor), Ravnikar, Maja (Avtor), Knežević, Miomir (Avtor), Rožman, Primož (Avtor), Jeras, Matjaž (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028761 Novo okno

Izvleček
Background: Different immunotherapy approaches for the treatment of cancer andautoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex ććcrossomicsćć analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4+T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20% of metabolites and less than 10% of genes, were identified as highly variable in our dataset. Conclusions/Significance: Our study shows that the intra-individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective.

Jezik:Angleški jezik
Ključne besede:imunoterapija, protitelesa, statistična analiza, genska ekspresija
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. e28761
Številčenje:Vol. 7, no. 1
UDK:616.1
ISSN pri članku:1932-6203
COBISS.SI-ID:3192689 Povezava se odpre v novem oknu
Število ogledov:448
Število prenosov:142
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:PloS one
Založnik:Public Library of Science
COBISS.SI-ID:2005896 Novo okno

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