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New insights into adipose tissue dysfunction in insulin resistance
Mlinar, Barbara (Avtor), Marc, Janja (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm.2011.697/cclm.2011.697.xml?rskey=3MJurx&result=1&q=New%20insights%20into%20adipose%20tissue%20dysfunction%20in%20insulin%20resistance Povezava se odpre v novem oknu

Izvleček
In a state of caloric excess, adipose tissue plays an essential role by storing lipids. Its expandability determines the onset of metabolic syndrome (central obesity, dyslipidemia, glucose intolerance and hypertension). When the adipocyte endoplasmic reticulum is no longer capable of processing the excess nutrients, the so-called "endoplasmic reticulum stress" develops. This triggers efflux of free fatty acids from adipocytes into the circulation and causes triglyceride overload in skeletal muscle, liver and pancreas. Adipose tissue hypoxia then develops, due to the failure of vasculature to expand with adipocyte hypertrophy. Increased catabolism in mitochondria leads there to oxidative stress. Both phenomena cause deranged adipokine secretion and low-grade inflammation. Inflammatory cytokines, reactive oxygen species and ectopic lipid deposition are the main mediators of insulin resistance and vascular impairment, which both lead finally to diabetes type 2 and cardiovascular disease. Recently, fibrosis of adipose tissue was also demonstrated in obesity, contributing to the interplay of deleterious factors forcing inflammation. The present paper reviews recent evidence for adipose tissue dysfunction, trying to define causes and consequences. In conclusion, insulin resistance and associated complications originate from excess lipids, which cannot be stored without limit in adipose tissue, thus affecting its integrity and adipokine secretion.

Jezik:Angleški jezik
Ključne besede:fibroza, hipoksija, metabolni sindrom, oksidativni stres, debelost
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2011
Št. strani:str. 1925-1935
Številčenje:Vol. 49, no. 12
UDK:61+612
ISSN pri članku:1434-6621
COBISS.SI-ID:3188593 Povezava se odpre v novem oknu
Število ogledov:826
Število prenosov:327
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Clinical chemistry and laboratory medicine
Skrajšan naslov:Clin Chem Lab Med
Založnik:Walter de Gruyter
ISSN:1434-6621
COBISS.SI-ID:1826580 Povezava se odpre v novem oknu

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