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An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
Mašić, Ivana (Avtor), German Ilić, Ilija (Avtor), Dreu, Rok (Avtor), Ibrić, Svetlana (Avtor), Parojčić, Jelena (Avtor), Đurić, Zorica (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0378517311011392 Povezava se odpre v novem oknu

Izvleček
The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule sizeand size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and goodflow properties. The results obtained indicate that conventional fluid bedgranulator may be suitable for production of highly spherical agglomerates,particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absenceof interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.

Jezik:Angleški jezik
Ključne besede:granuliranje, delci, farmacevtska tehnologija
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 202-212
Številčenje:Vol. 423, no. 2
UDK:661.12
ISSN pri članku:0378-5173
DOI:10.1016/j.ijpharm.2011.12.013 Povezava se odpre v novem oknu
COBISS.SI-ID:3186033 Povezava se odpre v novem oknu
Število ogledov:821
Število prenosov:196
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Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Povezava se odpre v novem oknu

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