An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
Mašić, Ivana (Author), German Ilić, Ilija (Author), Dreu, Rok (Author), Ibrić, Svetlana (Author), Parojčić, Jelena (Author), Đurić, Zorica (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0378517311011392 This link opens in a new window

The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule sizeand size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and goodflow properties. The results obtained indicate that conventional fluid bedgranulator may be suitable for production of highly spherical agglomerates,particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absenceof interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.

Keywords:granuliranje, delci, farmacevtska tehnologija
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 202-212
Numbering:Vol. 423, no. 2
ISSN on article:0378-5173
DOI:10.1016/j.ijpharm.2011.12.013 Link is opened in a new window
COBISS.SI-ID:3186033 Link is opened in a new window
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Record is a part of a journal

Title:International journal of pharmaceutics
Shortened title:Int. j. pharm.
COBISS.SI-ID:3087631 This link opens in a new window

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