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IL-23 dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination
Gopal, Radha (Avtor), Lin, Yinyao (Avtor), Obermajer, Nataša (Avtor), Slight, Samantha (Avtor), Nuthalapati, Nikhil (Avtor), Ahmed, Mushtaq (Avtor), Kalinski, Pawel (Avtor), Khader, Shabaana A. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://onlinelibrary.wiley.com/doi/10.1002/eji.201141569/abstract Povezava se odpre v novem oknu

Izvleček
The generation of effective type 1 T helper (Th1) cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)-17 to drive Th1-cell immunity and subsequent protective host immunity. Here, in a model of Mycobacterium bovis Bacille Calmette Guerin (BCG) vaccination in mice, we demonstrate that the dependence on IL-17 to drive Th1-cell responses is a host mechanism to overcome bacteria-induced IL-10 inhibitory effects. We show that BCG-induced prostaglandin-E2 (PGE2) promotes the production of IL-10 which limits Th1-cellresponses, while simultaneously inducing IL-23 and Th17-cell differentiation. The ability of IL-17 to down-regulate IL-10 and induce IL-12 production allows the generation of subsequent Th1-cell responses. Accordingly, BCG-induced Th17-cell responses precede the generation of Th1-cell responses in vivo, while the absence of the IL-23 pathway decreases BCG vaccine-induced Th17 and Th1-cell immunity and subsequent vaccine-induced protection upon M.tuberculosis challenge. Importantly, in the absence of IL-10, BCG-induced Th1-cell responses occur in an IL-17-independent manner. These novel data demonstrate a role for the IL-23/IL-17 pathway in driving Th1-cell responses, specifically to overcome IL-10 mediated inhibition and, furthermore, show that in the absence of IL-10, the generation of BCG-induced Th1-cell immunity is IL-17-independent.

Jezik:Angleški jezik
Ključne besede:imunska regulacija, T-celice, imunska odzivnost, dendritične celice
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 364-373
Številčenje:Vol. 42, issue 2
UDK:577.2
ISSN pri članku:0014-2980
DOI:10.1002/eji.201141569 Povezava se odpre v novem oknu
COBISS.SI-ID:3164273 Povezava se odpre v novem oknu
Število ogledov:744
Število prenosov:208
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Gradivo je del revije

Naslov:European Journal of Immunology
Skrajšan naslov:Eur J Immunol
Založnik:Verlag Chemie GmbH, Academic Press
ISSN:0014-2980
COBISS.SI-ID:25429248 Povezava se odpre v novem oknu

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