izpis_h1_title_alt

LFA-1 fine-tuning by cathepsin X
Jevnikar, Zala (Avtor), Obermajer, Nataša (Avtor), Kos, Janko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://onlinelibrary.wiley.com/doi/10.1002/iub.505/abstract;jsessionid=F030F236C6DD33491D9D5F5CAA8F9A04.d01t02 Novo okno

Izvleček
The adhesion molecule lymphocyte function-associated antigen (LFA)-1 plays a key role in immune surveillance and response. Its conformation is spatially and temporally regulated, enabling adhesion and deadhesion during T-cell migration. LFA-1 adhesion to its major ligand intercellular adhesion molecule 1 is controlled by adaptor proteins which bind the cytoplasmic tail of the ? (2) subunit. Cathepsin X, a cysteine carboxypeptidase, promotes T-cell migration and morphological changes by cleaving the ? (2) cytoplasmic tail of LFA-1. In this way, it modulates the affinity of LFA-1 for structural adaptorstalin-1 and ?-actinin-1 and enables the stepwise transition between intermediate and high-affinity conformations of LFA-1, an event that is necessary for effective T-cell function. Cathepsin X regulation that would allow precise modulation of LFA-1 affinity has a great potential for anti-LFA-1 therapy.

Jezik:Angleški jezik
Ključne besede:katepsin X, LFA-1, T-celice
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2011
Št. strani:str. 686-693
Številčenje:Vol. 63, no. 9
UDK:577.2
ISSN pri članku:1521-6543
COBISS.SI-ID:3138673 Povezava se odpre v novem oknu
Število ogledov:595
Število prenosov:86
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na: Bookmark and Share

Gradivo je del revije

Naslov:IUBMB life
Založnik:Taylor & Francis
ISSN:1521-6543
COBISS.SI-ID:14540327 Novo okno

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj