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The industrial and academic rationale of Caco-2 cell models today
Berginc, Katja (Avtor), Zvonar Pobirk, Alenka (Avtor), Gašperlin, Mirjana (Avtor), Kristl, Albin (Avtor)

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Izvleček
The application of CACO-2 cell models as a supportive in vitro tool during drug discovery and formulation development aims to address the per oral absorption of drug candidates with different degrees of predictive efficiency,depending on the inherent CACO-2 cell characteristics and on the intra-laboratory quality control protocols. Although CACO-2 cell permeability studies probe a certain subset of experimental questions, careful interpretation of the obtained data should be exercised on more complex issues, which include the interplay between multiple biological functions. In the first part of the presented paper the academic applicability of CACO-2 cells for investigating drug-food interactions arising as a consequence of modified transporter activities will be demonstrated. To illustrate these claims, the suitability of the CACO-2 cell monolayers as a reliable instrumentin predicting the absorption will be manifested first. Then the impact of garlic supplement (aged garlic extract) on the permeability of selected cardiovascular, antidiabetic and antiviral drugs will be presented and compared to the permeability determined through the isolated segments of a rat's small intestine. Based on the provided review regarding the (dis)similarities in the transporter and enzyme expression between this cancerous cell line and intestinal tissue, the observed qualitative pharmacokinetic transporter-drug interactions will be considered in the context of their in vivo relevance.

Jezik:Angleški jezik
Ključne besede:CaCo-2 celice, permeabilne študije, česnovi ekstrakti, dostavni sistemi
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.16 - Samostojni znanstveni sestavek ali poglavje v monografski publikaciji
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2011
Št. strani:Str. 1-30
UDK:579.6
COBISS.SI-ID:3130737 Povezava se odpre v novem oknu
Število ogledov:675
Število prenosov:98
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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