izpis_h1_title_alt

A new approach to enhance oral bioavailability of Silybum Marianum dry extract: association of mechanochemical activation and spray congealing
Passerini, N. (Avtor), Perissutti, Beatrice (Avtor), Albertini, B. (Avtor), Franceschinis, Erica (Avtor), Lenaz, Davide (Avtor), Hasa, Dritan (Avtor), Locatelli, Igor (Avtor), Voinovich, Dario (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0944711311002339 Povezava se odpre v novem oknu

Izvleček
The aim of the work was to produce a delivery system for Silybum Marianum dry extract with enhanced oral bioavailability by combining two technologies (mechanochemical activation and spray congealing). Initially, the active was coground with sodium croscarmellose in a planetary mill in order to reach an activated state more prone to dissolution. DSC, XRD, FT-IR and LD analyses showed the formation of nanosized particles of dry extract, with reduced degree of crystallinity of the main crystalline flavolignans (silybine A and B). Then, microparticles containing the activated coground and, as comparison,the corresponding physical mixture of extract and polymer and the dry extract alone were produced by spray congealing technology using Gelucirer50/13 as a hydrophilic low m.p. carrier. Microparticles containing the activated coground were produced spherical in shape, achieved satisfactory yield and high encapsulation efficiency. These microparticles, in addition to a favourable in vitro solubilisation kinetic, in a preliminary in vivo study in five rats demonstrated their ability to improve very significantly the oral bioavailability of the main flavolignans of Silybum Marianum dry extract (silybin A and B). These results suggested that the association of mechanochemical activation and spray congealing could be considered an innovative and very useful approach to the oral delivery of Silybum Marianum. Furthermore, for the first time the possibility of successfully applying the spray congealing technology for the preparation of a herbal drug delivery system was shown.

Jezik:Angleški jezik
Ključne besede:Silybum Marianum, strjevanje spreja, trdni lipidni mikrodelci, oralna biološka razpoložljivost
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 160-168
Številčenje:Vol. 19, issue 2
UDK:542:615
ISSN pri članku:0944-7113
DOI:10.1016/j.phymed.2011.06.027 Povezava se odpre v novem oknu
COBISS.SI-ID:3093361 Povezava se odpre v novem oknu
Število ogledov:594
Število prenosov:242
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Phytomedicine
Skrajšan naslov:Phytomedicine
Založnik:Fischer
ISSN:0944-7113
COBISS.SI-ID:17566981 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj