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Physical properties of pharmaceutical pellets
Šibanc, Rok (Avtor), Kitak, Teja (Avtor), Janković, Biljana (Avtor), Srčič, Stanko (Avtor), Dreu, Rok (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science/article/pii/S0009250912002631 Povezava se odpre v novem oknu

Izvleček
A series of various methods were applied to characterize samples of pharmaceutical pellets. Fourteen pellet types were tested to obtain the coefficient of restitution, coefficient of friction, stiffness, flowability, and distribution of size, shape, and density. An atomic force microscope was used to determine the pellet surface properties. The values obtained for the coefficient of restitution ranged from 0.568 to 0.843, and a sample-specific dependence of impact velocity was demonstrated. Mean pellet size was between 807.2 and 1271 Žm, granular density ranged between 1.086 and 1.483 g/ml, and the coefficient of friction was around 0.21 for pellet-steel contact and around 0.16 for pellet-glass contact. AFM provided information about surface stiffness and roughness; furthermore, the values obtained correlated well with the results of other methods. The values of Youngʼs modulus of the pellets using the plate compression method or AFM surface testing were close to 1 GPa. The database of properties of commercially available sample pellets presented here represents a solid foundation for sound CFD and DEM simulations of pharmaceutical processes connected with the production of dosage forms comprising pellets.

Jezik:Angleški jezik
Ključne besede:farmacevtska industrija, pelete, simulacije, granuliranje
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:Str. 50-60
UDK:661.12+66.099
ISSN pri članku:0009-2509
COBISS.SI-ID:3076721 Povezava se odpre v novem oknu
Število ogledov:731
Število prenosov:186
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del zbornika

Naslov:5th International Granulation Workshop
COBISS.SI-ID:3357297 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:Chemical Engineering Science
Skrajšan naslov:Chem. eng. sci.
Založnik:Pergamon Press
ISSN:0009-2509
COBISS.SI-ID:838916 Povezava se odpre v novem oknu

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