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TNFRSF11B gene polymorphisms 1181G > C and 245T > G as well as haplotype CT influence bone mineral density in postmenopausal women
Mencej Bedrač, Simona (Author), Preželj, Janez (Author), Marc, Janja (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0378512211000454 This link opens in a new window

Abstract
OBJECTIVES: Osteoprotegerin (OPG) inhibits osteoclast function by acting as adecoy receptor for receptor activator of nuclear factor-?B ligand (RANKL), thus being an important candidate gene for osteoporosis. Three recent genome-wide association studies also identified the TNFRSF11B gene, coding for OPG, as playing a key role in bone mineral density (BMD) regulation. As variations in the TNFRSF11B gene could alter the susceptibility to osteoporosis, the aim of study was to investigate association of two TNFRSF11B gene polymorphisms with BMD and serum OPG concentration in postmenopausal women. STUDY DESIGN: 478 postmenopausal women were genotyped for the presence of TNFRSF11B gene polymorphisms 245T > G (rs3134069) and 1181G > C (rs2073618). BMDs and serum OPG concentrations were measured. RESULTS: Two common haplotypes GT and CT occurred in 41.2% and 52.4% of subjects. In osteoporotic postmenopausal women, lumbar spine BMD was associated with polymorphisms 245T > G and 1181G > C, as well as with CT haplo type (p values 0.013, 0.006 and 0.006, respectively). Additionally, femoral neck BMD showed the association with 245T > G (p = 0.047). No other statistically significant associations with BMD were found for the studied SNPs and haplotypes. No association with serum OPG concentration was shown in any of the studied groups. CONCLUSIONS: Our results suggest that, in postmenopausal osteoporosis, polymorphisms 245T > G and 1181G > C, as well as haplotype CT in TNFRSF11B gene influence BMD.

Language:English
Keywords:osteoprotegerin, osteoporoza, SNP, serum OPG
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2011
Number of pages:str. 263-267
Numbering:Vol. 69, no. 3
UDC:577+616.7
ISSN on article:0378-5122
COBISS.SI-ID:3074929 Link is opened in a new window
Views:662
Downloads:248
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Record is a part of a journal

Title:Maturitas
Shortened title:Maturitas
Publisher:Elsevier/North-Holland
ISSN:0378-5122
COBISS.SI-ID:25916160 This link opens in a new window

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