PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: A pilot study
Dragojevič, Jana (Author), Ostanek, Barbara (Author), Mencej Bedrač, Simona (Author), Komadina, Radko (Author), Preželj, Janez (Author), Marc, Janja (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S0009912011013907 This link opens in a new window

OBJECTIVES: Peroxisome proliferator-activated receptor ? (PPAR?), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly. DESIGN AND METHODS: Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype onfracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls. RESULTS: The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor ?B ligand. CONCLUSIONS: The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.

Keywords:osteoporoza, RANKL, genetika, mineralna kostna gostota
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 1085-1089
Numbering:Vol. 44, no. 13
ISSN on article:0009-9120
COBISS.SI-ID:3074673 Link is opened in a new window
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Title:Clinical biochemistry
Shortened title:Clin. biochem.
COBISS.SI-ID:22275033 This link opens in a new window

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