izpis_h1_title_alt

Mapping the local elastic properties of pharmaceutical solids using atomic force microscopy
Janković, Biljana (Avtor), Škarabot, Miha (Avtor), Ilić, Ilija (Avtor), Planinšek, Odon (Avtor), Muševič, Igor (Avtor), Srčič, Stanko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=1770020359&_sort=r&_st=13&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=0da47d29e2e895b5d36f3430b6f705bc&searchtype=a Povezava se odpre v novem oknu

Izvleček
Elastic modulus of commonly used excipient, i.e. microcrystalline cellulose (MCC) and an active pharmaceutical ingredient (API), i.e. clarithromycin has been measured by atomic force microscopy. Moderate forces applied with AFM cantilever caused small deformations (a few nanometers) of investigated samples and under such conditions the Hertz model was successfully applied. Wide distributions of the measured elastic modulus imply on heterogeneous surface properties of the investigated samples. This could be explained by polycrystalline attributes of clarithromycin and coarse structure of MCC agglomerates. AFM-based nanoindentation method was compared to a permanent indentation technique performed by nanoindenter. Results obtained by applying larger forces using nanoindenter showed a significant indentation depth dependence that could be the consequence of materialćs non-ideally elastic surface or viscoelastic/plastic properties.

Jezik:Angleški jezik
Ključne besede:nanomehanika, farmacevtske snovi, atomska mikroskopija, AFM
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2011
Št. strani:str. 2866-2875
Številčenje:Vol. 10
UDK:539.2
DOI:10.1016/j.proeng.2011.04.475 Povezava se odpre v novem oknu
COBISS.SI-ID:3039089 Povezava se odpre v novem oknu
Število ogledov:452
Število prenosov:151
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj