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Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
Mirković, Bojana (Author), Renko, Miha (Author), Turk, Samo (Author), Sosič, Izidor (Author), Jevnikar, Zala (Author), Obermajer, Nataša (Author), Turk, Dušan (Author), Gobec, Stanislav (Author), Kos, Janko (Author)

URLURL - Presentation file, Visit http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201100098/abstract This link opens in a new window

Abstract
A new trick for an old dog! Aberrant cathepsin B activity is associated with tumor progression, however, despite extensive research, there are no cathepsinB inhibitors in clinical use. Here, nitroxoline, an established antimicrobial agent, is identified as a potent, reversible inhibitor of cathepsin B, and is thus a potential drug candidate for the treatment of cancer and other diseases in which cathepsin B activity plays a role.

Language:English
Keywords:antitumorna zdravila, rak, katepsin B, encimski inhibitorji, nitroksolin
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2011
Number of pages:str. 1351-1356
Numbering:Vol. 6, iss. 8
UDC:577.2:615.2
ISSN on article:1860-7179
DOI:10.1002/cmdc.201100098 Link is opened in a new window
COBISS.SI-ID:3024241 Link is opened in a new window
Views:567
Downloads:177
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Record is a part of a journal

Title:ChemMedChem
Publisher:Wiley-VCH Verlag GmbH
ISSN:1860-7179
COBISS.SI-ID:27051781 This link opens in a new window

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